Management of Recurrent Gastrointestinal Stromal Tumors

被引：15

作者：

Winer, Joshua H. ^{[1
,2
]}

Raut, Chandrajit P. ^{[1
,2
,3
]}

机构：

[1] Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Dana Farber Canc Inst, Ctr Sarcoma & Bone Oncol, Boston, MA 02115 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2011年 / 104卷 / 08期

关键词：

recurrent gastrointestinal stromal tumor; imatinib mesylate; sunitinib malate; surgery; neoadjuvant therapy; blood level testing; PHASE-II TRIAL; IMATINIB MESYLATE; SURGICAL RESECTION; RESIDUAL DISEASE; TYROSINE-KINASE; DOSE IMATINIB; GIST; THERAPY; SURGERY; KIT;

D O I：

10.1002/jso.21890

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recurrence after resection of primary gastrointestinal stromal tumor (GIST) is an unfortunately all-too-common phenomenon. The principal treatment for recurrent GIST is the first-line tyrosine kinase inhibitor (TKI) imatinib mesylate. Those who progress on, or are intolerant of imatinib, are treated with second-line TKI sunitinib malate. Cytoreductive surgery may be considered as an "adjuvant" therapy for patients with disease stabilized on imatinib, and, on an individual basis, sunitinib. J. Surg. Oncol. 2011;104:915-920. (C) 2011 Wiley Periodicals, Inc.

引用

页码：915 / 920

页数：6

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