Antibody responses to influenza A(H1N1)pdm infection

被引：3

作者：

Wraith, Steph ^{[1
]}

Nachbagauer, Raffael ^{[3
,4
,5
]}

Balmaseda, Angel ^{[6
,7
]}

Stadlbauer, Daniel ^{[3
,4
,5
]}

Ojeda, Sergio ^{[7
,8
]}

Rajabhathor, Arvind ^{[3
,4
,5
]}

Lopez, Roger ^{[6
,7
]}

Guglia, Andrea F. ^{[3
,4
,5
]}

Sanchez, Nery ^{[7
,8
]}

Amanat, Fatima ^{[3
,4
,5
]}

Gresh, Lionel ^{[7
]}

Kuan, Guillermina ^{[7
,8
]}

Krammer, Florian ^{[3
,4
,5
]}

Gordon, Aubree ^{[1
,2
,3
]}

机构：

[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA

[2] St Jude Ctr Excellence Influenza Res & Surveillan, Memphis, TN USA

[3] Ctr Excellence Influenza Res & Surveillance CEIRS, Memphis, TN USA

[4] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[5] Ctr Res Influenza Pathogenesis CRIP, New York, NY USA

[6] Minist Hlth, Ctr Nacl Diagnost & Referencia, Lab Nacl Virol, Managua, Nicaragua

[7] Sustainable Sci Inst, Managua, Nicaragua

[8] Minist Hlth, Ctr Salud Socrates Flores Vivas, Managua, Nicaragua

来源：

VACCINE | 2020年 / 38卷 / 27期

关键词：

Influenza; Antibodies; Neuraminidase; Hemagglutination inhibition; PROTECTION; VACCINE;

D O I：

10.1016/j.vaccine.2020.04.069

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated humoral immune response to influenza A(H1N1)pdm infection and found 32 (22%) of the infected individuals identified by PCR failed to produce a >= 4-fold hemagglutinin inhibition assay (HAI) response; a subset of 18 (56%) produced an alternate antibody response (against full-length HA, HA stalk, or neuraminidase). These individuals had lower pre-existing HAI antibody titers and showed a pattern of milder illness. An additional subset of 14 (44%) did not produce an alternate antibody response, had higher pre-existing antibody titers against full-length & stalk HA, and were less sick. These findings demonstrate that some individuals mount an alternate antibody response to influenza infection. In order to design more broadly protective influenza vaccines it may be useful to target these alternate sites. These findings support that there are influenza cases currently being missed by solely implementing HAI assays, resulting in an underestimation of the global burden of influenza infection. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页码：4221 / 4225

页数：5

共 50 条

[11] Protective antibody responses against A(H1N1)pdm09 primed by infection and recalled by intranasal vaccination
Ikeda, Kazuyuki
Ainai, Akira
Hasegawa, Hideki
VACCINE, 2015, 33 (45) : 6066 - 6069
[12] Serum anti-neuraminidase antibody responses in human influenza A(H1N1)pdm09 virus infections
Karunarathna, Herath M. T. K.
Perera, Ranawaka A. P. M.
Fang, Vicky J.
Yen, Hui-ling
Cowling, Benjamin John
Peiris, Malik
EMERGING MICROBES & INFECTIONS, 2019, 8 (01): : 404 - 412
[13] Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses
Daulagala, Pavithra
Mann, Brian R.
Leung, Kathy
Lau, Eric H. Y.
Yung, Louise
Lei, Ruipeng
Nizami, Sarea I. N.
Wu, Joseph T.
Chiu, Susan S.
Daniels, Rodney S.
Wu, Nicholas C.
Wentworth, David
Peiris, Malik
Yen, Hui-Ling
MBIO, 2023, 14 (03):
[14] Pediatric neurological complications associated with the A(H1N1)pdm09 influenza infection
Frobert, E.
Sarret, C.
Billaud, G.
Gillet, Y.
Escuret, V.
Floret, D.
Casalegno, J. S.
Bouscambert, M.
Morfin, F.
Javouhey, E.
Lina, B.
JOURNAL OF CLINICAL VIROLOGY, 2011, 52 (04) : 307 - 313
[15] Influenza A(H1N1)pdm09 virus infection in marine mammals in California
Boyce, Walter M.
Mena, Ignacio
Yochem, Pamela K.
Gulland, Frances M. D.
Garcia-Sastre, Adolfo
Moreno, Noelia
Perez, Daniel R.
Gonzalez-Reiche, Ana S.
Stewart, Brent S.
EMERGING MICROBES & INFECTIONS, 2013, 2
[16] Influenza A(H1N1) pdm09 Virus Infection in Giant Pandas, China
Li, Desheng
Zhu, Ling
Cui, Hengmin
Ling, Shanshan
Fan, Shengtao
Yu, Zhijun
Zhou, Yuancheng
Wang, Tiecheng
Qian, Jun
Xia, Xianzhu
Xu, Zhiwen
Gao, Yuwei
Wang, Chengdong
EMERGING INFECTIOUS DISEASES, 2014, 20 (03) : 480 - 483
[17] INFECTION WITH INFLUENZA-A H1N1 .1. PRODUCTION AND PERSISTENCE OF ANTIBODY
GRILLI, EA
DAVIES, JR
SMITH, AJ
JOURNAL OF HYGIENE, 1986, 96 (02) : 335 - 343
[18] H1N1 influenza A infection: an update
Dotis, J.
Roilides, E.
HIPPOKRATIA, 2009, 13 (04) : 254 - 254
[19] Influenza A (H1N1) infection in pigs
Brookes, Sharon M.
Irvine, Richard M.
Nunez, Alejandro
Clifford, Derek
Essen, Steve
Brown, Ian H.
Van Reeth, Kristien
Kuntz-Simon, Gaelle
Loeffen, Willie
Foni, Emanuela
Larsen, Lars
Matrosovich, Mikhail
Bublot, Michel
Maldonado, Jaime
Beer, Martin
Cattoli, Giovanni
VETERINARY RECORD, 2009, 164 (24) : 760 - 761
[20] Seroprevalence of Influenza A(H1N1) pdm09 Virus Antibody, England, 2010 and 2011
Hoschler, Katja
Thompson, Catherine
Andrews, Nick
Galiano, Monica
Pebody, Richard
Ellis, Joanna
Stanford, Elaine
Baguelin, Marc
Miller, Elizabeth
Zambon, Maria
EMERGING INFECTIOUS DISEASES, 2012, 18 (11) : 1894 - 1897

← 1 2 3 4 5 →