Antibody responses to influenza A(H1N1)pdm infection

被引：3
|
作者：
Wraith, Steph [1 ]
Nachbagauer, Raffael [3 ,4 ,5 ]
Balmaseda, Angel [6 ,7 ]
Stadlbauer, Daniel [3 ,4 ,5 ]
Ojeda, Sergio [7 ,8 ]
Rajabhathor, Arvind [3 ,4 ,5 ]
Lopez, Roger [6 ,7 ]
Guglia, Andrea F. [3 ,4 ,5 ]
Sanchez, Nery [7 ,8 ]
Amanat, Fatima [3 ,4 ,5 ]
Gresh, Lionel [7 ]
Kuan, Guillermina [7 ,8 ]
Krammer, Florian [3 ,4 ,5 ]
Gordon, Aubree [1 ,2 ,3 ]
机构：
[1] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
[2] St Jude Ctr Excellence Influenza Res & Surveillan, Memphis, TN USA
[3] Ctr Excellence Influenza Res & Surveillance CEIRS, Memphis, TN USA
[4] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA
[5] Ctr Res Influenza Pathogenesis CRIP, New York, NY USA
[6] Minist Hlth, Ctr Nacl Diagnost & Referencia, Lab Nacl Virol, Managua, Nicaragua
[7] Sustainable Sci Inst, Managua, Nicaragua
[8] Minist Hlth, Ctr Salud Socrates Flores Vivas, Managua, Nicaragua
来源：
VACCINE | 2020年 / 38卷 / 27期
关键词：
Influenza; Antibodies; Neuraminidase; Hemagglutination inhibition; PROTECTION; VACCINE;
D O I：
10.1016/j.vaccine.2020.04.069
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated humoral immune response to influenza A(H1N1)pdm infection and found 32 (22%) of the infected individuals identified by PCR failed to produce a >= 4-fold hemagglutinin inhibition assay (HAI) response; a subset of 18 (56%) produced an alternate antibody response (against full-length HA, HA stalk, or neuraminidase). These individuals had lower pre-existing HAI antibody titers and showed a pattern of milder illness. An additional subset of 14 (44%) did not produce an alternate antibody response, had higher pre-existing antibody titers against full-length & stalk HA, and were less sick. These findings demonstrate that some individuals mount an alternate antibody response to influenza infection. In order to design more broadly protective influenza vaccines it may be useful to target these alternate sites. These findings support that there are influenza cases currently being missed by solely implementing HAI assays, resulting in an underestimation of the global burden of influenza infection. (C) 2020 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4221 / 4225
页数：5
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