The TRITON clinical trial programme: Evaluation of the PARP inhibitor rucaparib in patients (Pts) with metastatic castration-resistant prostate cancer (mCRPC) associated with homologous recombination deficiency (HRD)

被引:0
|
作者
Chowdhury, S. [1 ,2 ]
Abida, W. [3 ]
Arranz Arija, J. [4 ]
Daugaard, G. [5 ]
Fizazi, K. [6 ]
Gez, E. [7 ]
Heidenreich, A. [8 ]
Joly Lobbedez, F. [9 ]
McDermott, R. [10 ]
Merseburger, A. S. [11 ]
Piulats Rodriguez, J. M. [12 ]
Sautois, B. [13 ]
Sridhar, S. [14 ]
Sternberg, C. N. [15 ]
Watkins, S. [16 ]
Simmons, A. [17 ]
Shetty, S. [18 ]
Golsorkhi, A. [19 ]
Ryan, C. J.
Scher, H. [3 ,20 ]
机构
[1] Guys Hosp, Urol Canc, London, England
[2] Sarah Cannon Res Inst, London, England
[3] Mem Sloan Kettering Canc Ctr, Genitourinary Oncol, 1275 York Ave, New York, NY 10021 USA
[4] Hosp Gen Univ Gregorio Maranon, Med Oncol, Madrid, Spain
[5] Copenhagen Univ Hosp, Rigshospitalet, Oncol, Copenhagen, Denmark
[6] Univ Paris, Grp Urogenitol, Villejuif, France
[7] Sourasky Med Ctr, Dept Oncol, Tel Aviv, Israel
[8] Univ Klinikum Koln, Klin Urol, Cologne, Germany
[9] Ctr Francois Baclesse, Med Oncol, Caen, France
[10] Tallaght & St Vincents Univ Hosp & Canc Trials Ir, Genitourinary Oncol, Dublin, Ireland
[11] Lubeck Univ Hosp, Urol Oncol, Lubeck, Germany
[12] Inst Catalan Oncol, Med Oncol, Barcelona, Spain
[13] Univ Hosp Liege, Med Oncol, Liege, Belgium
[14] Princess Margaret Hosp, Med Oncol, Toronto, ON, Canada
[15] San Camillo Forlanini Hosp, Dept Oncol, Rome, Italy
[16] Clovis Oncol Inc, Clin Sci, Boulder, CO USA
[17] Clovis Oncol Inc, Boulder, CO USA
[18] Clovis Oncol Inc, Clin Operat, Boulder, CO USA
[19] Clovis Oncol Inc, Clin Dev, Boulder, CO USA
[20] UCSF Helen Diller Family Comprehens Canc Ctr, Genitourinary Med Oncol, San Francisco, CA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
836TiP
引用
收藏
页数:1
相关论文
共 50 条
  • [11] Preliminary results from TRITON2: A phase II study of rucaparib in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) associated with homologous recombination repair (HRR) gene alterations
    Abida, W.
    Bryce, A. H.
    Vogelzang, N. J.
    Amato, R. J.
    Percent, I.
    Shapiro, J. D.
    McDermott, R.
    Hussain, A.
    Patnaik, A.
    Petrylak, D.
    Ryan, C. J.
    Stanton, T.
    Zhang, J.
    Simmons, A. D.
    Despain, D.
    Collins, M.
    Golsorskhi, T.
    Scher, H. I.
    Chowdhury, S.
    ANNALS OF ONCOLOGY, 2018, 29 : 272 - 272
  • [12] A phase II trial in progress: Pamiparib, an investigational PARP inhibitor, in patients with metastatic castration-resistant prostate cancer and a circulating tumor cell homologous recombination deficiency (HRD) phenotype or BRCA defects.
    Chowdhury, Simon
    Mateo, Joaquin
    Gross, Mitchell
    Armstrong, Andrew J.
    Cruz-Correa, Marcia
    Piulats, Josep M.
    Blay, Jean-Yves
    Rivas, Delcia
    Quintero, Luis
    Castro, Henry
    Nkobena, Andong
    Raponi, Mitch
    Pelham, Robert
    Landers, Mark Andrew
    Montgomery, Robert B.
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (07)
  • [13] Second-Line Therapy for Patients with metastatic castration-refractory Prostate Cancer (mCRPC) An international, randomized, open-label, Phase 3 Study of the PARP Inhibitor Rucaparib versus Physicians Choice of Treatment for Patients with metastatic castration-resistant Prostate Cancer (mCRPC) associated with homologous Recombination Deficiency (TRITON3) - AP 100/18 of the AUO
    Rexer, H.
    Graefen, M.
    Merseburger, A.
    AKTUELLE UROLOGIE, 2019, 50 (05) : 478 - 479
  • [14] Rucaparib population pharmacokinetics (PPK) and exposure-response (ER) analyses in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) in TRITON2
    Chowdhury, S.
    Patnaik, A.
    Campbell, D.
    Shapiro, J.
    Bryce, A. H.
    McDermott, R.
    Sautois, B.
    Vogelzang, N. J.
    Bambury, R.
    Voog, E.
    Zhang, J.
    Green, M.
    Beltman, J.
    Despain, D.
    Simmons, A. D.
    Watkins, S. P.
    Golsorkhi, A.
    Xiao, J.
    Abida, W.
    ANNALS OF ONCOLOGY, 2020, 31 : S533 - S534
  • [15] Tolerability of olaparib (OLA) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) and homologous recombination repair (HRR) gene alterations: PROfound
    Roubaud, G.
    Ozguroglu, M.
    Penel, N.
    Matsubara, N.
    Mehra, N.
    Kolinsky, M. P.
    Procopio, G.
    Feyerabend, S.
    Joung, J. Y.
    Gravis, G.
    Nishimura, K.
    Gedye, C.
    Padua, C.
    Shore, N.
    Thiery-Vuillemin, A.
    Gresty, C.
    Brickel, N.
    Burgents, J.
    Allen, A.
    Fizazi, K.
    ANNALS OF ONCOLOGY, 2020, 31 : S515 - S516
  • [16] Statin use and outcome in metastatic castration-resistant prostate cancer (mCRPC) patients (pts) treated in the TROPIC trial
    Lorente, D.
    De Velasco Oria, G. A.
    Carles, J.
    Gillessen, S.
    Fizazi, K.
    Joshua, A.
    Eisenberger, M.
    Sartor, O.
    de Bono, J. S.
    ANNALS OF ONCOLOGY, 2018, 29
  • [17] Real-world effectiveness of PARP inhibitors (PARPi) in metastatic castration-resistant prostate cancer (mCRPC) by genomic homologous recombination repair (HRR) alterations and homologous recombination deficiency signature (HRDsig).
    Triner, Daniel
    Graf, Ryon
    Gjoerup, Ole
    Tukachinsky, Hanna
    Ross, Jeffrey S.
    Cheng, Heather H.
    Pritchard, Colin C.
    Zurita, Amado J.
    Mateo, Joaquin
    Cieslik, Marcin
    Morgan, Todd Matthew
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (4_SUPPL) : 186 - 186
  • [18] Metronomic Oral Cyclophosphamide in 2 Heavily Pretreated Patients With Metastatic Castration-resistant Prostate Cancer With Homologous Recombination Deficiency (HRD): A Case Report
    Ling, Hang Huong
    Lin, Yung-Chang
    CLINICAL GENITOURINARY CANCER, 2019, 17 (02) : 157 - 160
  • [19] Genomic characteristics associated with clinical activity of rucaparib in patients (pts) with BRCA1 or BRCA2 (BRCA)-mutated metastatic castration-resistant prostate cancer (mCRPC)
    Abida, Wassim
    Campbell, David
    Patnaik, Akash
    Sautois, Brieuc
    Shapiro, Jeremy David
    Vogelzang, Nicholas J.
    Bryce, Alan Haruo
    McDermott, Raymond S.
    Ricci, Francesco
    Rowe, Julie Haewon
    Zhang, Jingsong
    Loehr, Andrea
    Despain, Darrin
    Dowson, Melanie
    Golsorkhi, Tony
    Chowdhury, Simon
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (06)
  • [20] Prediction of PARP inhibitor response and resistance utilizing a CTC phenotypic classifer in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Results from the NCI 9012 trial
    Feng, F. Y.
    Daignault-Newton, S.
    Jendrisak, A.
    Wang, Y.
    Greene, S.
    Rodriguez, A.
    Lee, J.
    Dugan, L.
    Siddiqui, J.
    Louw, J.
    Johnson, C.
    Twardowski, P.
    Albany, C.
    Stein, M.
    Stadler, W. M.
    Kunju, L.
    Chinnaiyan, A. M.
    Landers, M.
    Dittamore, R.
    Hussain, M.
    ANNALS OF ONCOLOGY, 2016, 27