CXCL12/CXCR4 Delivers Pro-Apoptotic Activity in FLT3/ITD+ Cells by Antagonizing Expression of Genes Deregulated by FLT3/ITD

被引：0

作者：

Fukuda, Seiji ^{[1
]}

Hirade, Tomohiro ^{[1
]}

Onishi, Chie ^{[2
]}

Taketani, Takeshi ^{[1
]}

机构：

[1] Shimane Univ, Dept Pediat, Matsue, Shimane, Japan

[2] Shimane Univ, Sch Med, Dept Oncol & Hematol, Matsue, Shimane, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2018年 / 65卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

OS27-3-4

引用

页码：S84 / S84

页数：1

共 50 条

[31] Bone Marrow Stromal Cells Protect Both FLT3-ITD and FLT3-WT Primary AML Cells from the Anti-Leukemic Activity of the FLT3 Inhibitor AC220
Dos Santos, Cedric
Ndikuyeze, Georges Habineza
Nisssan, Michael
Zhou, Chenghui
Shan, Xiaochuan
Perl, Alexander E.
Carroll, Martin P.
Danet-Desnoyers, Gwenn
BLOOD, 2014, 124 (21)
[32] FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche
Williams, Kirsten M.
Moore, Amber R.
Lucas, Philip J.
Wang, Juin
Bare, Catherine V.
Gress, Ronald E.
EXPERIMENTAL HEMATOLOGY, 2017, 52 : 40 - 49
[33] Heat shock protein 90 (Hsp90) inhibition results in apoptotic killing of primary AML cells with FLT3/ITD mutation.
Al-Shaer, LM
Gilkes, AF
Mills, KI
Burnett, AK
Rowntree, CJ
BLOOD, 2004, 104 (11) : 692A - 692A
[34] Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression
Deepika Arora
Susanne Köthe
Monique van den Eijnden
Rob Hooft van Huijsduijnen
Florian Heidel
Thomas Fischer
Sebastian Scholl
Benjamin Tölle
Sylvia-Annette Böhmer
Johan Lennartsson
Fabienne Isken
Carsten Müller-Tidow
Frank-D Böhmer
Cell Communication and Signaling, 10
[35] Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression
Arora, Deepika
Koethe, Susanne
van den Eijnden, Monique
van Huijsduijnen, Rob Hooft
Heidel, Florian
Fischer, Thomas
Scholl, Sebastian
Toelle, Benjamin
Boehmer, Sylvia-Annette
Lennartsson, Johan
Isken, Fabienne
Mueller-Tidow, Carsten
Boehmer, Frank-D
CELL COMMUNICATION AND SIGNALING, 2012, 10
[36] STUDYING THE ROLE OF PIM KINASES IN FLT3-ITD-INDUCED LEUKEMIA REVEALED PIM1 AS REGULATOR OF CXCL12/CXCR4-MEDIATED HOMING AND MIGRATION
Brault, L.
Grundler, R.
Gasser, C.
Bullock, A. N.
Ehret, S.
Spoo, A.
Dierks, C.
Biondi, A.
Knapp, S.
Duyster, J.
Schwaller, J.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 448 - 449
[37] Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis (vol 289, pg 31053, 2014)
Onishi, Chie
Mori-Kimachi, Satomi
Hirade, Tomohiro
Abe, Mariko
Taketani, Takeshi
Suzumiya, Junji
Sugimoto, Toshitsugu
Yamaguchi, Seiji
Kapur, Reuben
Fukuda, Seiji
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (47) : 28356 - 28356
[38] Promotion of chimerism and tolerance by Flt3 ligand-mobilized facilitating cells is associated with upregulation of CXCR4 and SDF-1.
Huang, YM
Kucia, M
Rezzoug, F
Ratajczak, MZ
Tanner, M
Schanie, C
Xu, H
Fugier, I
Ildstad, ST
BLOOD, 2004, 104 (11) : 363A - 363A
[39] CXCR4 synergistically activates FLT3 receptor and regulates mobilization of innate immune and stem progenitor cells post-myocardial infarction
Ayach, B. B.
Higuchi, K.
Dawood, F.
Lam, K.
Chen, M.
Tata, N.
Stewart, D. J.
Stanford, W. L.
Medin, J. A.
Liu, P. P.
CANADIAN JOURNAL OF CARDIOLOGY, 2007, 23 : 159C - 159C
[40] FLT3 inhibitors upregulate CXCR4 and E-selectin ligands via ERK suppression in AML cells and CXCR4/E-selectin inhibition enhances anti-leukemia efficacy of FLT3-targeted therapy in AML
Jia, Yannan
Zhang, Weiguo
Basyal, Mahesh
Chang, Kyung Hee
Ostermann, Lauren
Burks, Jared K. K.
Ly, Charlie
Mu-Mosley, Hong
Zhang, Qi
Han, Xin
Fogler, William E. E.
Magnani, John L. L.
Lesegretain, Arnaud
Zal, Anna A. A.
Zal, Tomasz
Andreeff, Michael
LEUKEMIA, 2023, 37 (06) : 1379 - 1383

← 1 2 3 4 5 →