The aim of this study was to evaluate the influence of primary and secondary appraisal, and of coping strategies, on daily stress, taking in-to account any possible effect of the big five personality traits. Over 10 days, a cohort of 122 people filled out an on-line diary in which they rec-orded the most important stressful event each day, their primary and sec-ondary appraisal of this, and how they coped with it. The results indicate that negative affect is influenced by a high degree of primary appraisal, lim-ited secondary appraisal and a high rate of refusal, with no significant in-fluence of personality traits. Positive affect is mainly influenced by a lower extent of primary appraisal, more secondary appraisal, and by a low rate of refusal and of social support seeking. Moreover, a low level of neuroticism was a predictor of greater positive affect. These data are discussed, high-lighting the importance of a situational assessment of stressful episodes at each moment to not only understand the effects of stress on health but al-so, to develop effective interventions.