Association analyses identify six new psoriasis susceptibility loci in the Chinese population

被引：264

作者：

Sun, Liang-Dan ^{[1
,2
,3
,4
]}

Cheng, Hui ^{[1
,2
,3
,4
]}

Wang, Zai-Xing ^{[1
,2
,3
,4
]}

Zhang, An-Ping ^{[1
,2
,3
,4
]}

Wang, Pei-Guang ^{[1
,2
,3
,4
]}

Xu, Jin-Hua ^{[5
]}

Zhu, Qi-Xing ^{[1
,2
,3
,4
]}

Zhou, Hai-Sheng ^{[4
,6
]}

Ellinghaus, Eva ^{[7
]}

Zhang, Fu-Ren ^{[3
,8
]}

Pu, Xiong-Ming ^{[3
,9
]}

Yang, Xue-Qin ^{[3
,10
]}

Zhang, Jian-Zhong ^{[11
]}

Xu, Ai-E ^{[3
,12
]}

Wu, Ri-Na ^{[13
]}

Xu, Li-Min ^{[14
]}

Peng, Lin ^{[15
]}

Helms, Cynthia A. ^{[15
]}

Ren, Yun-Qing ^{[1
,2
,3
,4
]}

Zhang, Chi ^{[1
,2
,3
,4
]}

Zhang, Shu-Mei ^{[1
,2
,4
]}

Nair, Rajan P. ^{[16
]}

Wang, Hong-Yan ^{[1
,2
,3
,4
]}

Lin, Guo-Shu ^{[1
,2
,3
,4
]}

Stuart, Philip E. ^{[16
]}

Fan, Xing ^{[1
,2
,3
,4
]}

Chen, Gang ^{[3
,4
]}

Tejasvi, Trilokraj ^{[16
]}

Li, Pan ^{[1
,2
,3
,4
]}

Zhu, Jun ^{[1
,2
,3
,4
]}

Li, Zhi-Ming ^{[1
,2
,3
,4
]}

Ge, Hong-Mei ^{[1
,2
,3
,4
]}

Weichenthal, Michael ^{[17
]}

Ye, Wen-Zheng ^{[1
,2
,3
,4
]}

Zhang, Cheng ^{[1
,2
,3
,4
]}

Shen, Song-Ke ^{[1
,2
,3
,4
]}

Yang, Bao-Qi ^{[8
]}

Sun, Yuan-Yuan ^{[1
,2
,3
,4
]}

Li, Shan-Shan ^{[1
,2
,3
,4
]}

Lin, Yan ^{[1
,2
,3
,4
]}

Jiang, Jian-Hua ^{[9
]}

Li, Cun-Tao ^{[1
,2
,3
,4
]}

Chen, Ri-Xin ^{[1
,2
,3
,4
]}

Cheng, Juan ^{[10
]}

Jiang, Xin ^{[1
,2
,3
,4
]}

Zhang, Peng ^{[1
,2
,3
,4
]}

Song, Wei-Min ^{[12
]}

Tang, Jin ^{[1
,2
,3
,4
]}

Zhang, Hao-Qin ^{[1
,2
,3
,4
]}

Sun, Li

机构：

[1] Anhui Med Univ, Inst Dermatol, Hosp 1, Hefei, Anhui, Peoples R China

[2] Anhui Med Univ, Dept Dermatol, Hosp 1, Hefei, Anhui, Peoples R China

[3] Anhui Med Univ, Dept Dermatol & Venereol, Hefei, Anhui, Peoples R China

[4] Minist Natl Sci & Technol, State Key Lab Incubat Base Dermatol, Hefei, Anhui, Peoples R China

[5] Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200433, Peoples R China

[6] Anhui Med Univ, Dept Biochem & Mol Biol, Hefei, Anhui, Peoples R China

[7] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

[8] Shandong Prov Inst Dermatol & Venereol, Jinan, Shandong, Peoples R China

[9] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Dermatol, Urumqi, Xinjiang, Peoples R China

[10] Gen Hosp Air Force, Dept Dermatol, Beijing, Peoples R China

[11] Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100871, Peoples R China

[12] Third Peoples Hosp Hangzhou, Hangzhou, Zhejiang, Peoples R China

[13] Affiliated Hosp, Inner Mongolia Med Coll, Dept Dermatol, Hohhot, Inner Mongolia, Peoples R China

[14] Changzheng Hosp, Dept Dermatol, Tianjin, Peoples R China

[15] Washington Univ, Sch Med, Div Human Genet, St Louis, MO USA

[16] Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

[17] Univ Hosp Schleswig Holstein, Dept Dermatol, Kiel, Germany

[18] Genome Inst Singapore, Singapore, Singapore

来源：

NATURE GENETICS | 2010年 / 42卷 / 11期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; ENDOTHELIAL GROWTH-FACTOR; GENE-CLUSTER; IDENTIFICATION; EXPRESSION; VARIANTS; SYSTEM; ERAP1;

D O I：

10.1038/ng.690

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 x 10(-8)) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 x 10(-21)) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 x 10(-3) and P = 7.9 x 10(-3), respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 x 10(-3) and P = 1.5 x 10(-3), respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.

引用

页码：1005 / U132

页数：7

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