Bacterial population genomics and infectious disease diagnostics

被引:28
|
作者
Joseph, Sandeep J. [1 ]
Read, Timothy D. [1 ,2 ]
机构
[1] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA
关键词
DNA MICROARRAY; GENETIC-RELATIONSHIPS; RAPID DETECTION; MULTIPLEX PCR; IDENTIFICATION; EVOLUTION; HYBRIDIZATION; ASSAY; POLYMORPHISMS; TRANSMISSION;
D O I
10.1016/j.tibtech.2010.09.001
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
New sequencing technologies have made the production of bacterial genome sequences increasingly easy, and it can be confidently forecasted that vast genomic databases will be generated in the next few years Here, we detail how collections of bacterial genomes from a particular species (population genomics libraries) have already been used to improve the design of several diagnostic assays for bacterial pathogens Genome sequencing itself is also becoming more commonly used for epidemiological, forensic and clinical investigations There is an opportunity for the further development of bioinformatic tools to bring even further value to bacterial diagnostic genomics
引用
收藏
页码:611 / 618
页数:8
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