LOW DOSE IL-2 CIRCUMVENTED MTOR SIGNALING IN T CELLS IN THE TREATMENT OF SLE

被引：0
|
作者：
He, J. [1 ]
Sun, X. [1 ]
Li, J. [1 ]
Zhang, R. [1 ]
Yu, D. [2 ]
Li, Z. [1 ]
机构：
[1] Peking Univ, Peoples Hosp, Beijing, Peoples R China
[2] Monash Univ, Sch Biomed Sci, Melbourne, Vic, Australia
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2017年 / 76卷
关键词：
D O I：
10.1136/annrheumdis-2017-eular.3482
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
AB0141
引用
收藏
页码：1096 / 1096
页数：1
相关论文
共 50 条
  • [41] Therapeutic potential of low-dose IL-2 in a chronic GVHD patient by in vivo expansion of regulatory T cells
    Kim, Nayoun
    Jeon, Young-Woo
    Nam, Young-Sun
    Lim, Jung-Yeon
    Im, Keon-Il
    Lee, Eun-Sol
    Cho, Seok-Goo
    CYTOKINE, 2016, 78 : 22 - 26
  • [42] Regulatory T cell abnormalities are linked to IL-2 deficiency in patients with SLE
    von Spee-Mayer, C.
    Rose, A.
    Klaus, A.
    Humrich, J.
    Riemekasten, G.
    ZEITSCHRIFT FUR RHEUMATOLOGIE, 2013, 72 : 46 - 46
  • [43] IL-2 unresponsiveness in anergic CD4+ T cells is due to defective signaling through the common γ-chain of the IL-2 receptor
    Grundström, S
    Dohlsten, M
    Sundstedt, A
    JOURNAL OF IMMUNOLOGY, 2000, 164 (03): : 1175 - 1184
  • [44] LOW-DOSE IL-2 THERAPY IN SLE: RESULTS FROM A COMBINED PHASE I/IIA CLINICAL TRIAL
    Humrich, J.
    Von Spee-Mayer, C.
    Siegert, E.
    Bertolo, M.
    Rose, A.
    Abdirama, D.
    Enghard, P.
    Hiepe, F.
    Radbruch, A.
    Burmester, G. -R.
    Riemekasten, G.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2016, 34 (04) : S13 - S13
  • [45] LOW-DOSE IL-2 THERAPY IN REFRACTORY SLE: INSIGHTS FROM A PHASE I/IIA CLINICAL TRIAL
    Humrich, J. Y.
    von Spee-Mayer, C.
    Siegert, E.
    Bertolo, M.
    Abdirama, D.
    Rose, A.
    Enghard, P.
    Radbruch, A.
    Burmester, G. R.
    Riemekasten, G.
    ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : A58 - A58
  • [46] EFFICACY OF LOW DOSE AND SHORT-TERM IL-2 TREATMENT TO EXPAND ENDOGENOUS REGULATORY T CELLS IN PATIENTS WITH MIXED CONNECTIVE TISSUE DISEASE
    Zhang, B.
    Shang, L. L.
    Cao, J. P.
    Gao, H. Y.
    Gao, C.
    Li, X. F.
    ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : 1266 - 1266
  • [47] Functional characteristics of porcine peripheral T cells stimulated with IL-2 or IL-2 and PMA
    Cheon, In Su
    Park, Sung-Moo
    Lee, Hye Jin
    Hong, Ji Eun
    Ji, Sang Yun
    Shim, Byoung-Shik
    Kim, Kwang Ho
    Heo, Pil Seung
    Kim, Yoo Yong
    Jung, Hyun Jung
    Ka, Hakhyun
    Han, Seung Hyun
    Song, Manki
    Yun, Cheol-Heui
    RESEARCH IN VETERINARY SCIENCE, 2014, 96 (01) : 54 - 61
  • [48] Signaling T cell survival and death by IL-2 and IL-15.
    Zambriciki, E
    Shigeoka, A
    Kishimoto, H
    Sprent, J
    Burakoff, S
    Carpenter, C
    Milford, E
    McKay, D
    AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 : 434 - 434
  • [49] IL-1 SIGNALING FOR IL-2 PRODUCTION IN T-CELLS INVOLVES A RISE IN PHOSPHATIDYLSERINE SYNTHESIS
    DIDIER, M
    AUSSEL, C
    PELASSY, C
    FEHLMANN, M
    JOURNAL OF IMMUNOLOGY, 1988, 141 (09): : 3078 - 3080
  • [50] Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells
    Nagy, Eva
    Mocsar, Gabor
    Sebestyen, Veronika
    Volko, Julianna
    Papp, Ferenc
    Toth, Katalin
    Damjanovich, Sandor
    Panyi, Gyorgy
    Waldmann, Thomas A.
    Bodnar, Andrea
    Vamosi, Gyorgy
    BIOPHYSICAL JOURNAL, 2018, 114 (10) : 2473 - 2482
12345