bone marrow transplantation;
antithymocyte globulin;
viral infection;
CD4(+) cells;
D O I:
10.1038/sj.bmt.1702711
中图分类号:
Q6 [生物物理学];
学科分类号:
071011 ;
摘要:
A 22-year-old female with acute myeloid leukemia (AML) in complete remission received a conditioning regimen containing antithymocyte globulin for an unrelated bone marrow transplant (BMT). After BMT, the patient suffered from cytomegalovirus (CMV) pneumonitis with markedly high levels of CMV antigenemia, activated prothrombin time (APTT) prolongation, and subacute thyroiditis. Recovery of CD4(+) cells was delayed as long as 1 year after BMT, An association between these three episodes and viral infection due to the delayed recovery of CD4(+) cells is suggested.