Risk factors for incident dementia after stroke and transient ischemic attack

被引：107

作者：

Yang, Jie ^{[1
,2
,3
,4
]}

Wong, Adrian ^{[5
,6
]}

Wang, Zhaolu ^{[1
]}

Liu, Wenyan ^{[1
]}

Au, Lisa ^{[1
]}

Xiong, Yunyun ^{[7
]}

Chu, Winnie W. C. ^{[8
]}

Leung, Eric Y. L.

Cheng, Sirong

Lau, Christine ^{[1
]}

Chan, Anne Y. Y. ^{[1
]}

Lau, Alexander Y. L. ^{[1
]}

Fan, Florence ^{[1
]}

Ip, Vincent ^{[1
]}

Soo, Yannie ^{[1
]}

Leung, Thomas ^{[1
]}

Ho, Chi L. ^{[9
]}

Wong, Lawrence K. S. ^{[1
]}

Mok, Vincent C. T. ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

[2] Guangzhou Med Univ, Inst Neurosci, Key Lab Neurogenet & Channelopathies Guangdong Pr, Guangzhou, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Inst Neurosci, Ministiy Educ China, Guangzhou, Guangdong, Peoples R China

[4] Guangzhou Med Univ, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China

[5] Hong Kong Inst Educ, Ctr Psychosocial Hlth & Aging, Dept Psychol Studies, Tai Po, Hong Kong, Peoples R China

[6] Hong Kong Inst Educ, Ctr Psychosocial Hlth & Aging, Hong Kong, Hong Kong, Peoples R China

[7] Nanjing Univ, Jinling Hosp, Sch Med, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China

[8] Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China

[9] Hong Kong Sanat & Hosp, Dept Nucl Med, Hong Kong, Hong Kong, Peoples R China

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 01期

关键词：

Poststroke dementia; Vascular cognitive impairment; Brain atrophy; PiB-PET; Transient ischemic attack; VASCULAR COGNITIVE IMPAIRMENT; HEALTH-CARE PROFESSIONALS; WHITE-MATTER LESIONS; POSTSTROKE DEMENTIA; ATROPHY; RELIABILITY; STATEMENT; DISEASE;

D O I：

10.1016/j.jalz.2014.01.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: We hypothesized that chronic brain changes are important substrates for incident dementia after stroke and transient ischemic attack (TIA). Methods: We compared clinical and imaging features between patients with consecutive stroke/TIA with (n = 88) and without (n = 925) incident dementia at 3 to 6 months after a stroke/TIA. Pittsburg compound B (PiB) positron emission tomography was performed in 50 patients, including those with (n = 37) and without (n = 13) incident dementia. Results: Age, history of diabetes mellitus, severity of white matter changes (WMCs), and medial temporal lobe atrophy (MTLA) were associated with incident dementia. Alzheimer's disease (AD)-like PiB retention was found in 29.7% and 7.7% (P = .032) of patients with and without incident dementia, respectively. Conclusions: Chronic brain changes including WMCs, MTLA, and AD pathology are associated with incident dementia after stroke/TIA. Interventions targeting these chronic brain changes may reduce burden of vascular cognitive impairment. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：16 / 23

页数：8

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