Copper-mediated selective oxidation of a C-H bond

被引：40
|
作者：
Boldron, C
Gamez, P
Tooke, DM
Spek, AL
Reedijk, J
机构：
[1] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands
[2] Univ Utrecht, Dept Crystal & Struct Chem, NL-3584 CH Utrecht, Netherlands
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 23期
关键词：
biomimetic synthesis; C-H activation; copper; homogeneous catalysis; oxidation;
D O I：
10.1002/anie.200462946
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) An environmentally friendly procedure has been developed for the oxidation of 2,4,6-trimethylpheriol (TMP) at the para Csp3-H bond. Upon reaction with H2O2 in the presence of catalytic amounts of CuII and neocuproine in methanol at 65°C, 4-(methoxymethyl)-2,6-dimethylphenol (MDP) or 4-hydroxy-3,5- dimethylbenzaldehyde (HDB) is formed (see reaction). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3585 / 3587
页数：3
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