Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy

被引：10
|
作者：
Liu, Lingshan [1 ,2 ]
Zhou, Xiang [1 ,2 ]
Zheng, Rongrong [3 ]
Huang, Jiaqi [1 ,2 ]
Kong, Renjiang [1 ,2 ]
Li, Yanmei [1 ,2 ]
Wang, Chang [3 ]
Chen, Ali [3 ]
Li, Shiying [3 ]
Cheng, Hong [1 ,2 ]
机构：
[1] Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Peoples R China
[2] Southern Med Univ, Guangdong Prov Key Lab Construct & Detect Tissue, Guangzhou 510515, Peoples R China
[3] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou 511436, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 59期
基金：
中国国家自然科学基金;
关键词：
OXIDATIVE STRESS; CURCUMIN;
D O I：
10.1039/d1cc02318g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A chlorine e6 (Ce6) and curcumin (Cur) based self-delivery nanomedicine (CeCu) is prepared for chemotherapy sensitized photodynamic therapy (PDT). The chemotherapeutic agent of Cur could inhibit the TrxR activity to destroy the cellular ROS-defence system for enhanced PDT, which provides synergistic effects for tumor precision therapy in consideration of the unfavorable tumor microenvironments.
引用
收藏
页码：7296 / 7299
页数：4
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