Self-delivery nanomedicine for chemotherapy sensitized photodynamic therapy

被引：10

作者：

Liu, Lingshan ^{[1
,2
]}

Zhou, Xiang ^{[1
,2
]}

Zheng, Rongrong ^{[3
]}

Huang, Jiaqi ^{[1
,2
]}

Kong, Renjiang ^{[1
,2
]}

Li, Yanmei ^{[1
,2
]}

Wang, Chang ^{[3
]}

Chen, Ali ^{[3
]}

Li, Shiying ^{[3
]}

Cheng, Hong ^{[1
,2
]}

机构：

[1] Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Peoples R China

[2] Southern Med Univ, Guangdong Prov Key Lab Construct & Detect Tissue, Guangzhou 510515, Peoples R China

[3] Guangzhou Med Univ, Sch Pharmaceut Sci, Guangzhou 511436, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 59期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE STRESS; CURCUMIN;

D O I：

10.1039/d1cc02318g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chlorine e6 (Ce6) and curcumin (Cur) based self-delivery nanomedicine (CeCu) is prepared for chemotherapy sensitized photodynamic therapy (PDT). The chemotherapeutic agent of Cur could inhibit the TrxR activity to destroy the cellular ROS-defence system for enhanced PDT, which provides synergistic effects for tumor precision therapy in consideration of the unfavorable tumor microenvironments.

引用

页码：7296 / 7299

页数：4

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