Rhabdomyolysis caused by the moderate CYP3A4 inhibitor fluconazole in a patient on stable atorvastatin therapy: a case report and literature review

被引：12
|
作者：
Hsiao, S. -H. [1 ]
Chang, H. -J. [1 ]
Hsieh, T. -H. [2 ]
Kao, S. -M. [1 ]
Yeh, P. -Y. [1 ]
Wu, T. -J. [3 ,4 ]
机构：
[1] Natl Cheng Kung Univ Hosp, Dept Pharm, Tainan, Taiwan
[2] Natl Cheng Kung Univ, Dept Internal Med, Med Coll & Hosp, Tainan, Taiwan
[3] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan, Taiwan
[4] Natl Cheng Kung Univ, Coll Med, Tainan, Taiwan
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2016年 / 41卷 / 05期
关键词：
atorvastatin; drug interaction; fluconazole; rhabdomyolysis; FUSIDIC ACID; SIMVASTATIN; STATIN; SAFETY; AMIODARONE;
D O I：
10.1111/jcpt.12425
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
What is known and objectiveRhabdomyolysis is a severe potential adverse drug reaction of statin therapy. We report a case of rhabdomyolysis due to drug-drug interaction (DDI) between atorvastatin and fluconazole and review the literature. Case summaryA 70-year-old woman received atorvastatin for hyperlipidaemia without any problem for 4 years. When intravenous fluconazole was added for treating a fungal infection, rhabdomyolysis developed 2 weeks later. Removal of atorvastatin led to the resolution of her rhabdomyolysis. What is new and conclusionOur case demonstrates that in some subjects even a moderate CYP3A4 inhibitor such as fluconazole may lead to rhabdomyolysis in subjects receiving a statin. Characteristics of reported cases of rhabdomyolysis associated with drug interaction between statins and fluconazole.
引用
收藏
页码：575 / 578
页数：4
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