Cytotoxic limonoids from Brazilian Melia azedarach

被引：39
|
作者：
Zhou, HL
Hamazaki, A
Fontana, JD
Takahashi, H
Wandscheer, CB
Fukuyama, Y [1 ]
机构：
[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Inst Pharmacognosy, Tokushima 7708514, Japan
[2] Univ Fed Parana, Dept Pharm, BR-80310170 Curitiba, Parana, Brazil
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 10期
关键词：
tetranortriterpenoid; limonoid; Melia azedarach; cytotoxicity;
D O I：
10.1248/cpb.53.1362
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three new C-seco limonoids (1-3) and one new tetracyclic limonoid (4) were isolated from a methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Brazil, and their structures were elucidated by spectroscopic data analysis and comparison of spectral data with those of the previously known compounds. Among the limonoids isolated in the present study, compounds 3 and 4 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1 and 2 showed weak cytotoxicity.
引用
收藏
页码：1362 / 1365
页数：4
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