CD14 positive cells accelerate hematopoietic stem cell engraftment

被引：3

作者：

Pievani, Alice ^{[1
,2
,3
]}

Granata, Valentina ^{[1
]}

Desantis, Giacomo ^{[4
]}

Antolini, Laura ^{[5
]}

Ornaghi, Sara ^{[6
]}

Galleu, Antonio ^{[2
,3
]}

Biondi, Andrea ^{[7
]}

Gentner, Bernhard ^{[4
]}

Dazzi, Francesco ^{[2
,3
]}

Serafini, Marta ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Pediat, Ctr Ric M Tettamanti, Monza, Italy

[2] Kings Coll London, Sch Canc & Pharmacol Sci, London, England

[3] Kings Coll London, KHP Canc Res UK Ctr, London, England

[4] IRCCS San Raffaele Sci Inst, San Raffaele Telethon Inst Gene Therapy SR TIGET, Milan, Italy

[5] Univ Milano Bicocca, Dept Hlth Sci, Ctr Biostat Epidemiol Clin, Monza, Italy

[6] Univ Milano Bicocca, Fdn MBBM, Dept Obstet & Gynecol, Monza, Italy

[7] Fdn MBBM, San Gerardo Hosp, Pediat Hematol Oncol Unit, Dept Pediat, Monza, Italy

来源：

BONE MARROW TRANSPLANTATION | 2022年 / 57卷 / 06期

关键词：

UMBILICAL-CORD BLOOD; BONE-MARROW; TRANSPLANTATION; EXPANSION;

D O I：

10.1038/s41409-022-01662-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The improvement of hematopoietic stem and progenitor cell (HSPC) engraftment remains a high-priority goal when limited cell doses are available, such as in cord blood (CB) transplantation and HSC gene therapy. We observed that monocytes are highly effective at improving the engraftment of both CB-CD34(+) and lentivirus-transfected CD34(+) cells in a xenogeneic model of HSC transplantation. Moreover, monocytes, in particular the CD14(+)CD16(-) classical subset, in co-culture systems increase survival and stemness of CB-CD34(+) cells. Both soluble factors and direct-cell contact interactions, such as JAG/NOTCH and COX-2/PGE2 pathways, are critically involved in the HSC-monocyte crosstalk. Our results indicate that the infusion of monocytes improves engraftment when cell dose is a limiting factor.

引用

页码：942 / 948

页数：7

共 50 条

[31] Osteoblasts promote engraftment of allogeneic hematopoietic stem cells
El-Badri, NS
Wang, BY
Cherry
Good, RA
EXPERIMENTAL HEMATOLOGY, 1998, 26 (02) : 110 - 116
[32] In vivo functional imaging of hematopoietic stem cell engraftment
Stein, J
Askenasy, N
Farkas, D
Yaniv, I
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (02) : 1 - 1
[33] The effect of aging on hematopoietic stem cell homing and engraftment
Liang, Y
Van Zant, G
Szilvassy, SJ
BLOOD, 2004, 104 (11) : 730A - 730A
[34] Engraftment syndrome following hematopoietic stem cell transplantation
TR Spitzer
Bone Marrow Transplantation, 2001, 27 : 893 - 898
[35] CD14 is a unique membrane marker of porcine spermatogonial stem cells, regulating their differentiation
Park, Hyun-Jung
Lee, Won-Young
Park, Chankyu
Hong, Kwonho
Song, Hyuk
SCIENTIFIC REPORTS, 2019, 9 (1)
[36] CD14 dependent mechanisms of cell activation
Han, JH
Bohuslav, J
Jiang, Y
Kravchenko, VV
Lee, JD
Li, ZJ
Mathison, J
Richter, B
Tobias, P
Ulevitch, RJ
ENDOTOXIN AND SEPSIS: MOLECULAR MECHANISMS OF PATHOGENESIS, HOST RESISTANCE, AND THERAPY, 1998, 397 : 157 - 168
[37] CD14 is a unique membrane marker of porcine spermatogonial stem cells, regulating their differentiation
Hyun-Jung Park
Won-Young Lee
Chankyu Park
Kwonho Hong
Hyuk Song
Scientific Reports, 9
[38] Lymphocyte augmentation of hematopoietic stem cell engraftment is due to cooperative effects of CD8+T cells on CD34+cell migration.
Adams, GB
Chabner, KT
Foxall, RB
Rodriques, NP
Poznansky, MC
Scadden, DT
BLOOD, 2000, 96 (11) : 580A - +
[39] Engraftment syndrome: A complication of hematopoietic stem cell transplantation
Summers, E.
Frey, M. A.
Kurtzberg, J.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2007, 13 (02) : 148 - 148
[40] Engraftment syndrome following hematopoietic stem cell transplantation
Spitzer, TR
BONE MARROW TRANSPLANTATION, 2001, 27 (09) : 893 - 898

← 1 2 3 4 5 →