CD14 positive cells accelerate hematopoietic stem cell engraftment

被引：2

作者：

Pievani, Alice ^{[1
,2
,3
]}

Granata, Valentina ^{[1
]}

Desantis, Giacomo ^{[4
]}

Antolini, Laura ^{[5
]}

Ornaghi, Sara ^{[6
]}

Galleu, Antonio ^{[2
,3
]}

Biondi, Andrea ^{[7
]}

Gentner, Bernhard ^{[4
]}

Dazzi, Francesco ^{[2
,3
]}

Serafini, Marta ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Pediat, Ctr Ric M Tettamanti, Monza, Italy

[2] Kings Coll London, Sch Canc & Pharmacol Sci, London, England

[3] Kings Coll London, KHP Canc Res UK Ctr, London, England

[4] IRCCS San Raffaele Sci Inst, San Raffaele Telethon Inst Gene Therapy SR TIGET, Milan, Italy

[5] Univ Milano Bicocca, Dept Hlth Sci, Ctr Biostat Epidemiol Clin, Monza, Italy

[6] Univ Milano Bicocca, Fdn MBBM, Dept Obstet & Gynecol, Monza, Italy

[7] Fdn MBBM, San Gerardo Hosp, Pediat Hematol Oncol Unit, Dept Pediat, Monza, Italy

来源：

BONE MARROW TRANSPLANTATION | 2022年 / 57卷 / 06期

关键词：

UMBILICAL-CORD BLOOD; BONE-MARROW; TRANSPLANTATION; EXPANSION;

D O I：

10.1038/s41409-022-01662-1

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The improvement of hematopoietic stem and progenitor cell (HSPC) engraftment remains a high-priority goal when limited cell doses are available, such as in cord blood (CB) transplantation and HSC gene therapy. We observed that monocytes are highly effective at improving the engraftment of both CB-CD34(+) and lentivirus-transfected CD34(+) cells in a xenogeneic model of HSC transplantation. Moreover, monocytes, in particular the CD14(+)CD16(-) classical subset, in co-culture systems increase survival and stemness of CB-CD34(+) cells. Both soluble factors and direct-cell contact interactions, such as JAG/NOTCH and COX-2/PGE2 pathways, are critically involved in the HSC-monocyte crosstalk. Our results indicate that the infusion of monocytes improves engraftment when cell dose is a limiting factor.

引用

页码：942 / 948

页数：7

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