Antibiotic resistance is ancient: implications for drug discovery

被引：100
|
作者：
Wright, Gerard D. [1 ]
Poinar, Hendrik [2 ]
机构：
[1] McMaster Univ, MG DeGroote Inst Infect Dis Res, Dept Biochem & Biomed Sci, Hamilton, ON L8S 4K1, Canada
[2] McMaster Univ, McMaster Ancient DNA Ctr, Dept Anthropol, Hamilton, ON L8S 4L9, Canada
来源：
TRENDS IN MICROBIOLOGY | 2012年 / 20卷 / 04期
关键词：
antibiotic; ancient DNA; vancomycin; beta-lactamase; tetracycline; aminoglycoside; COMBINATIONS; RESISTOME;
D O I：
10.1016/j.tim.2012.01.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An unfailing observation over the past 70 years is that resistance to all antibiotics emerges eventually after use in the clinic. Where does this resistance come from? Recent work has shown that antibiotic resistance genes are common in metagenomes of ancient sediments. This prevalence of resistance, well before the use of antibiotics, denotes the importance of taking microbial chemical ecology and deep metagenomic profiling into account in the development and use of antibiotics.
引用
收藏
页码：157 / 159
页数：3
相关论文
共 50 条
  • [1] Antibiotic drug discovery: Challenges and perspectives in the light of emerging antibiotic resistance
    Bhattarai, Keshab
    Bastola, Rina
    Baral, Bikash
    ADVANCES IN GENETICS, VOL 105, 2020, 105 : 229 - 292
  • [2] Understanding the basis of antibiotic resistance: a platform for drug discovery
    Piddock, Laura J. V.
    MICROBIOLOGY-SGM, 2014, 160 : 2366 - 2373
  • [3] Protein promiscuity in drug discovery, drug-repurposing and antibiotic resistance
    Gupta, Munishwar N.
    Alam, Anwar
    Hasnain, Seyed E.
    BIOCHIMIE, 2020, 175 : 50 - 57
  • [4] Antibiotic resistance is ancient
    D'Costa, Vanessa M.
    King, Christine E.
    Kalan, Lindsay
    Morar, Mariya
    Sung, Wilson W. L.
    Schwarz, Carsten
    Froese, Duane
    Zazula, Grant
    Calmels, Fabrice
    Debruyne, Regis
    Golding, G. Brian
    Poinar, Hendrik N.
    Wright, Gerard D.
    NATURE, 2011, 477 (7365) : 457 - 461
  • [5] Antibiotic resistance is ancient
    Vanessa M. D’Costa
    Christine E. King
    Lindsay Kalan
    Mariya Morar
    Wilson W. L. Sung
    Carsten Schwarz
    Duane Froese
    Grant Zazula
    Fabrice Calmels
    Regis Debruyne
    G. Brian Golding
    Hendrik N. Poinar
    Gerard D. Wright
    Nature, 2011, 477 : 457 - 461
  • [6] Antibiotic drug discovery
    Wohlleben, Wolfgang
    Mast, Yvonne
    Stegmann, Evi
    Ziemert, Nadine
    MICROBIAL BIOTECHNOLOGY, 2016, 9 (05): : 541 - 548
  • [7] The problem of antimalarial resistance and its implications for drug discovery
    Schaefer, Thomas Martin
    Pessanha de Carvalho, Lais
    Inoue, Juliana
    Kreidenweiss, Andrea
    Held, Jana
    EXPERT OPINION ON DRUG DISCOVERY, 2024, 19 (02) : 209 - 224
  • [8] Computational resources in the management of antibiotic resistance: Speeding up drug discovery
    Maryam, Lubna
    Usmani, Salman Sadullah
    Raghava, Gajendra P. S.
    DRUG DISCOVERY TODAY, 2021, 26 (09) : 2138 - 2151
  • [9] Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution
    Bollenbach, Tobias
    CURRENT OPINION IN MICROBIOLOGY, 2015, 27 : 1 - 9
  • [10] Enterococcus faecalis multi-drug resistance transporters:: Application for antibiotic discovery
    Davis, DVR
    McAlpine, JB
    Pazoles, CJ
    Talbot, MK
    Alder, EA
    White, AC
    Jonas, BM
    Murray, BE
    Weinstock, GM
    Rogers, BL
    JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, 2001, 3 (02) : 179 - 184
12345