The problem of antimalarial resistance and its implications for drug discovery

被引:6
|
作者
Schaefer, Thomas Martin [1 ]
Pessanha de Carvalho, Lais [1 ]
Inoue, Juliana [1 ]
Kreidenweiss, Andrea [1 ,2 ,3 ]
Held, Jana [1 ,2 ,3 ]
机构
[1] Univ Tubingen, Inst Trop Med, Tubingen, Germany
[2] Ctr Rech Med Lambarene, Lambarene, Gabon
[3] German Ctr Infect Res DZ, Tubingen, Germany
关键词
Plasmodium falciparum; antimalarial drug resistance; artemisinin-based combination therapies; antimalarial drug discovery; irresistibles; PLASMODIUM-FALCIPARUM MALARIA; IN-VITRO EVOLUTION; ARTEMISININ RESISTANCE; CHLOROQUINE RESISTANCE; DIHYDROARTEMISININ-PIPERAQUINE; SULFADOXINE-PYRIMETHAMINE; COMBINATION THERAPIES; MEFLOQUINE RESISTANCE; ANTIFOLATE RESISTANCE; CROSS-RESISTANCE;
D O I
10.1080/17460441.2023.2284820
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
IntroductionMalaria remains a devastating infectious disease with hundreds of thousands of casualties each year. Antimalarial drug resistance has been a threat to malaria control and elimination for many decades and is still of concern today. Despite the continued effectiveness of current first-line treatments, namely artemisinin-based combination therapies, the emergence of drug-resistant parasites in Southeast Asia and even more alarmingly the occurrence of resistance mutations in Africa is of great concern and requires immediate attention.Areas CoveredA comprehensive overview of the mechanisms underlying the acquisition of drug resistance in Plasmodium falciparum is given. Understanding these processes provides valuable insights that can be harnessed for the development and selection of novel antimalarials with reduced resistance potential. Additionally, strategies to mitigate resistance to antimalarial compounds on the short term by using approved drugs are discussed.Expert opinionWhile employing strategies that utilize already approved drugs may offer a prompt and cost-effective approach to counter antimalarial drug resistance, it is crucial to recognize that only continuous efforts into the development of novel antimalarial drugs can ensure the successful treatment of malaria in the future. Incorporating resistance propensity assessment during this developmental process will increase the likelihood of effective and enduring malaria treatments.
引用
收藏
页码:209 / 224
页数:16
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