Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats

被引：9
|
作者：
Murillo-Rodriguez, Eric [1 ]
Vazquez-Luis, Edgar [2 ]
Millan-Aldaco, Diana [3 ]
Haro, Reyes [4 ]
Drucker-Colin, Rene [3 ]
机构：
[1] Univ Autonoma Campeche, Neurobiol Lab, Fac Med, Campeche, Mexico
[2] Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico
[3] Univ Nacl Autonoma Mexico, Dept Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico
[4] Univ Nacl Autonoma Mexico, Dept Fisiol, Fac Med, Clin Trastornos Sueno, Mexico City 04510, DF, Mexico
来源：
NEUROSCIENCE LETTERS | 2008年 / 436卷 / 02期
关键词：
waking; alpha power spectra; slow wave sleep; rapid eye movement sleep;
D O I：
10.1016/j.neulet.2008.03.048
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 mu L of MOD (10, 20, or 30 mu g) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：283 / 287
页数：5
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