Promoting of wakefulness by administrations of modafinil into anterior hypothalamus and into the pedunculopontine tegmental nucleus in rats

被引：9

作者：

Murillo-Rodriguez, Eric ^{[1
]}

Vazquez-Luis, Edgar ^{[2
]}

Millan-Aldaco, Diana ^{[3
]}

Haro, Reyes ^{[4
]}

Drucker-Colin, Rene ^{[3
]}

机构：

[1] Univ Autonoma Campeche, Neurobiol Lab, Fac Med, Campeche, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City 04510, DF, Mexico

[3] Univ Nacl Autonoma Mexico, Dept Neurociencias, Inst Fisiol Celular, Mexico City 04510, DF, Mexico

[4] Univ Nacl Autonoma Mexico, Dept Fisiol, Fac Med, Clin Trastornos Sueno, Mexico City 04510, DF, Mexico

来源：

NEUROSCIENCE LETTERS | 2008年 / 436卷 / 02期

关键词：

waking; alpha power spectra; slow wave sleep; rapid eye movement sleep;

D O I：

10.1016/j.neulet.2008.03.048

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated whether administration of MOD in rats during the lights-on period into wake-promoting areas, such as anterior hypothalamus (AH) or into the pedunculopontine tegmental nucleus (PPTg) would enhance waking. Results showed that microinjections of 1 mu L of MOD (10, 20, or 30 mu g) into both brain areas increased the total time of alertness and decreased sleep. Additionally, MOD-treated rats showed an enhancement in alpha power spectra but delta power spectra was diminished. Finally, c-Fos expression was found increased into either AH or the PPTg. Collectively, these results suggest that MOD induces waking via the activity of two wake-related brain areas such as AH and the PPTg. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：283 / 287

页数：5

共 50 条

[1] Infusion of modafinil into anterior hypothalamus or pedunculopontine tegmental nucleus at different time-points enhances waking and blocks the expression of recovery sleep in rats after sleep deprivation
Arias-Carrion, Oscar
Palomero-Rivero, Marcela
Millan-Aldaco, Diana
Haro, Reyes
Drucker-Colin, Rene
Murillo-Rodriguez, Eric
EXPERIMENTAL NEUROLOGY, 2011, 229 (02) : 358 - 363
[2] Calcium/Calmodulin Kinase II in the Pedunculopontine Tegmental Nucleus Modulates the Initiation and Maintenance of Wakefulness
Datta, Subimal
O'Malley, Matthew W.
Patterson, Elissa H.
JOURNAL OF NEUROSCIENCE, 2011, 31 (47): : 17007 - 17016
[3] Modafinil increases histamine release in the anterior hypothalamus of rats
Ishizuka, T
Sakamoto, Y
Sakurai, T
Yamatodani, A
NEUROSCIENCE LETTERS, 2003, 339 (02) : 143 - 146
[4] DIFFERENT FUNCTIONS OF RATS PEDUNCULOPONTINE TEGMENTAL NUCLEUS ARE REFLECTED IN CORTICAL EEG
BRINGMANN, A
NEUROREPORT, 1995, 6 (15) : 2065 - 2068
[5] Effects of pedunculopontine tegmental nucleus lesions on emotional reactivity and locomotion in rats
Homs-Ormo, S
Coll-Andreu, M
Satorra-Marín, W
Arévalo-García, R
Morgado-Bernal, I
BRAIN RESEARCH BULLETIN, 2003, 59 (06) : 495 - 503
[6] Cardiovascular effects of nitrergic system of the pedunculopontine tegmental nucleus in anesthetized rats
Shafei, Mohammad Naser
Nikyar, Tahereh
Hosseini, Mahmoud
Niazmand, Saeed
Paseban, Maryam
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2017, 20 (07) : 776 - 782
[7] EEG related neuronal activity in the pedunculopontine tegmental nucleus of urethane anaesthetized rats
Balatoni, B
Détári, L
BRAIN RESEARCH, 2003, 959 (02) : 304 - 311
[8] Cholinergic neurons in the pedunculopontine tegmental nucleus modulate breathing in rats by direct projections to the retrotrapezoid nucleus
Lima, Janayna D.
Sobrinho, Cleyton R.
Falquetto, Barbara
Santos, Leonardo K.
Takakura, Ana C.
Mulkey, Daniel K.
Moreira, Thiago S.
JOURNAL OF PHYSIOLOGY-LONDON, 2019, 597 (07): : 1919 - 1934
[9] PREPULSE INHIBITION OF ACOUSTIC STARTLE IN RATS AFTER LESIONS OF THE PEDUNCULOPONTINE TEGMENTAL NUCLEUS
SWERDLOW, NR
GEYER, MA
BEHAVIORAL NEUROSCIENCE, 1993, 107 (01) : 104 - 117
[10] Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats
Murillo-Rodriguez, Eric
Haro, Reyes
Palomero-Rivero, Marcela
Millan-Aldaco, Diana
Drucker-Colin, Rene
BEHAVIOURAL BRAIN RESEARCH, 2007, 176 (02) : 353 - 357

← 1 2 3 4 5 →