Associations between sleep duration and insulin resistance in European children and adolescents considering the mediating role of abdominal obesity

被引:17
|
作者
Thumann, Barbara F. [1 ,2 ,3 ]
Michels, Nathalie [2 ]
Felso, Regina [4 ]
Hunsberger, Monica [5 ]
Kaprio, Jaakko [6 ,7 ]
Moreno, Luis A. [8 ,9 ]
Siani, Alfonso [10 ]
Tornaritis, Michael [11 ]
Veidebaum, Toomas [12 ]
De Henauw, Stefaan [2 ]
Ahrens, Wolfgang [1 ,3 ]
Boernhorst, Claudia [1 ]
机构
[1] Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany
[2] Univ Ghent, Dept Publ Hlth & Primary Care, Fac Med & Hlth Sci, Ghent, Belgium
[3] Univ Bremen, Fac Math & Comp Sci, Bremen, Germany
[4] Univ Pecs, Dept Paediat, Ctr Clin, Pecs, Hungary
[5] Univ Gothenburg, Sahlgrenska Acad, Sect Epidemiol & Social Med EPSO, Gothenburg, Sweden
[6] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
[7] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland
[8] Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Inst Agroalimentario Aragon IA2, Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
[9] Univ Zaragoza, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Zaragoza, Spain
[10] CNR, Inst Food Sci, Avellino, Italy
[11] Res & Educ Inst Child Hlth, Strovolos, Cyprus
[12] Natl Inst Hlth Dev, Dept Chron Dis, Tallinn, Estonia
来源
PLOS ONE | 2020年 / 15卷 / 06期
关键词
CHILDHOOD OBESITY; CARDIOMETABOLIC RISK; REFERENCE VALUES; SERUM-INSULIN; OVERWEIGHT; INDEXES; GLUCOSE; HEALTH; VALIDATION; SECRETION;
D O I
10.1371/journal.pone.0235049
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Short sleep duration has been suggested to lead to insulin resistance both directly by altering glucose metabolism and indirectly through obesity. This study aims to investigate associations between nocturnal sleep duration and insulin resistance considering abdominal obesity as a mediator. Methods We analysed data of 3 900 children aged 2-15 years participating in the second (2009/10) and third (2013/14) examination wave of the European IDEFICS/I.Family study (hereafter referred to as baseline and follow-up). Information on nocturnal sleep duration was collected by questionnaires and age-standardised (SLEEP z-score). The homeostasis model assessment (HOMA) was calculated from fasting insulin and fasting glucose obtained from blood samples; waist circumference (WAIST) was measured with an inelastic tape. HOMA and WAIST were used as indicators for insulin resistance and abdominal obesity, respectively, and transformed to age- and sex-specific z-scores. Cross-sectional and longitudinal associations between SLEEP z-score and HOMA z-score were investigated based on a path model considering WAIST z-score as a mediator adjusting for relevant confounders. Results Cross-sectionally, baseline SLEEP z-score was negatively associated with baseline WAIST z-score (unstandardised effect estimate -0.120, 95% confidence interval [-0.167; -0.073]). We observed no direct effect of baseline SLEEP z-score on baseline HOMA z-score but a negative indirect effect through baseline WAIST z-score (-0.042 [-0.058; -0.025]). Longitudinally, there was no direct effect of baseline SLEEP z-score on HOMA z-score at follow-up but a negative indirect effect through both baseline WAIST z-score and WAIST z-score at follow-up (-0.028 [-0.040; -0.016]). Conclusions Our results do not support the hypothesis of an association between short sleep duration and insulin resistance independent of abdominal obesity. However, longer sleep duration may exert short and long term beneficial effects on insulin resistance through its beneficial effects on abdominal obesity.
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页数:19
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