Serotonin induces melanogenesis via serotonin receptor 2A

被引：45
|
作者：
Lee, H. J. [1 ]
Park, M. K. [1 ]
Kim, S. Y. [2 ]
Choo, H. Y. Park [3 ,4 ]
Lee, A. Y. [5 ]
Lee, C. H. [1 ]
机构：
[1] Dongguk Univ, Coll Pharm, Seoul 100715, South Korea
[2] Kyung Hee Univ, Grad Sch EW Med Sci, Yongin 446701, Gyeonggi Do, South Korea
[3] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
[4] Ewha Womans Univ, Div Life & Pharmaceut Sci, Seoul 120750, South Korea
[5] Dongguk Univ, Ilsan Hosp, Dept Dermatol, Coll Med, Goyang, South Korea
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2011年 / 165卷 / 06期
关键词：
LIZARD ANOLIS-CAROLINENSIS; SKIN PIGMENTATION; PROLIFERATION;
D O I：
10.1111/j.1365-2133.2011.10490.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background Serotonin (5-hydroxytryptamine, 5-HT) levels are increased by light exposure but the role and mechanism of 5-HT in the pigmentation of skin cells are unclear. Objectives To clarify the effect of 5-HT on melanogenesis and to determine the 5-HT receptor subtype involved. Methods B16F10, SK-MEL-2 and Melan-A cells were cultured in Dulbecco's modified Eagle's medium with low fetal bovine serum. The three cell lines were treated with various concentrations of 5-HT, and 5-HT receptor agonists and antagonists. The involvement of the 5-HT receptor 2A (5-HTR2A) was examined by gene silencing and use of 5-HTR2A antagonists. Results 5-HT and the 5-HTR2A agonist, DOI, increased melanogenesis in the three cell lines. These increased events were suppressed by 5-HTR2A antagonists or gene silencing of the HTR2A gene. Conclusions 5-HTR2A is involved in melanogenesis. These findings highlight the role of 5-HT and suggest new ways of controlling melanogenesis.
引用
收藏
页码：1344 / 1348
页数：5
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