Fe3O4-ZIF-8 assemblies as pH and glutathione responsive T2-T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

被引：70
|
作者：
Lin, Jiaomin [1 ,2 ]
Xin, Pengyan [1 ,2 ]
An, Lu [1 ,2 ]
Xu, Yanjun [3 ]
Tao, Cheng [1 ,2 ]
Tian, Qiwei [1 ,2 ]
Zhou, Zhiguo [1 ,2 ]
Hu, Bing [3 ]
Yang, Shiping [1 ,2 ]
机构：
[1] Shanghai Normal Univ, Minist Educ, Key Lab Resource Chem, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China
[2] Shanghai Normal Univ, Shanghai Municipal Educ Comm, Key Lab Mol Imaging Probes & Sensors, Shanghai 200234, Peoples R China
[3] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Ultrasound Med, Shanghai Inst Ultrasound Med, Shanghai 200233, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 04期
基金：
中国国家自然科学基金;
关键词：
IRON-OXIDE NANOPARTICLES; METAL-ORGANIC FRAMEWORKS; ONE-POT SYNTHESIS; DESIGN; TARGET;
D O I：
10.1039/c8cc08943d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A small Fe3O4 nanoparticles-based T-1 contrast agent was assembled into a pH- and glutathione-responsive T-2-T-1 switching contrast agent, Fe3O4-ZIF-8. In vivo T-1-weighted images of mice showed that Fe3O4-ZIF-8 displayed darkening contrast enhancement for liver sites, while darkening to brightening contrast enhancement at tumor sites, giving large inverse contrast for distinguishing the normal and tumor tissues.
引用
收藏
页码：478 / 481
页数：4
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