Fe3O4-ZIF-8 assemblies as pH and glutathione responsive T2-T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

被引：70

作者：

Lin, Jiaomin ^{[1
,2
]}

Xin, Pengyan ^{[1
,2
]}

An, Lu ^{[1
,2
]}

Xu, Yanjun ^{[3
]}

Tao, Cheng ^{[1
,2
]}

Tian, Qiwei ^{[1
,2
]}

Zhou, Zhiguo ^{[1
,2
]}

Hu, Bing ^{[3
]}

Yang, Shiping ^{[1
,2
]}

机构：

[1] Shanghai Normal Univ, Minist Educ, Key Lab Resource Chem, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

[2] Shanghai Normal Univ, Shanghai Municipal Educ Comm, Key Lab Mol Imaging Probes & Sensors, Shanghai 200234, Peoples R China

[3] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Ultrasound Med, Shanghai Inst Ultrasound Med, Shanghai 200233, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 04期

基金：

中国国家自然科学基金;

关键词：

IRON-OXIDE NANOPARTICLES; METAL-ORGANIC FRAMEWORKS; ONE-POT SYNTHESIS; DESIGN; TARGET;

D O I：

10.1039/c8cc08943d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A small Fe3O4 nanoparticles-based T-1 contrast agent was assembled into a pH- and glutathione-responsive T-2-T-1 switching contrast agent, Fe3O4-ZIF-8. In vivo T-1-weighted images of mice showed that Fe3O4-ZIF-8 displayed darkening contrast enhancement for liver sites, while darkening to brightening contrast enhancement at tumor sites, giving large inverse contrast for distinguishing the normal and tumor tissues.

引用

页码：478 / 481

页数：4

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