The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

被引：30

作者：

Lupu, Diana ^{[1
,2
,3
]}

Andersson, Patrik ^{[4
]}

Bornehag, Carl-Gustaf ^{[5
]}

Demeneix, Barbara ^{[6
]}

Fritsche, Ellen ^{[7
]}

Gennings, Chris ^{[8
]}

Lichtensteiger, Walter ^{[9
]}

Leist, Marcel ^{[10
]}

Leonards, Pim E. G. ^{[11
]}

Ponsonby, Anne-Louise ^{[12
]}

Scholze, Martin ^{[13
]}

Testa, Giuseppe ^{[14
]}

Tresguerres, Jesus A. E. ^{[15
]}

Westerink, Remco H. S. ^{[16
]}

Zalc, Bernard ^{[17
]}

Ruegg, Joelle ^{[1
,2
]}

机构：

[1] Uppsala Univ, Evolutionary Biol Ctr, S-75236 Uppsala, Sweden

[2] Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden

[3] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Toxicol, Cluj Napoca 400012, Romania

[4] Umea Univ, Fac Sci & Technol, S-90187 Umea, Sweden

[5] Karlstad Univ, Dept Hlth Sci, S-65188 Karlstad, Sweden

[6] CNRS, Evolut Endocrine Regulat UMR 7221, F-75005 Paris, France

[7] IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany

[8] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA

[9] GREEN Tox GmbH, CH-8057 Zurich, Switzerland

[10] Univ Konstanz, In Vitro Toxicol & Biomed, D-78457 Constance, Germany

[11] Vrije Univ, Dept Environm & Hlth, NL-1081 HV Amsterdam, Netherlands

[12] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[13] Brunel Univ London, Inst Environm Hlth & Soc, Uxbridge UB8 3PH, Middx, England

[14] Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy

[15] Univ Complutense Madrid, Sch Med, Dept Physiol, Madrid 28040, Spain

[16] Univ Utrecht, Fac Vet Med, Inst Risk Assessment Sci IRAS, NL-3584 CM Utrecht, Netherlands

[17] Sorbonne Univ, INSERM, CNRS, ICM GH Pitie Salpetriere, F-75651 Paris, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 11期

基金：

欧盟地平线“2020”;

关键词：

endocrine-disrupting chemicals; developmental neurotoxicity; chemical testing; adverse outcome pathways; PERINATAL EXPOSURE; BRAIN-DEVELOPMENT; RECEPTORS; CHILDHOOD; BEHAVIOR; DNT; DIFFERENTIATION; HIPPOCAMPUS; CHEMICALS;

D O I：

10.3390/ijms21113978

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.

引用

页数：16

共 26 条

[21] Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing
Zimmer, B.
Kuegler, P. B.
Baudis, B.
Genewsky, A.
Tanavde, V.
Koh, W.
Tan, B.
Waldmann, T.
Kadereit, S.
Leist, M.
CELL DEATH AND DIFFERENTIATION, 2011, 18 (03): : 383 - 395
[22] Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing
B Zimmer
P B Kuegler
B Baudis
A Genewsky
V Tanavde
W Koh
B Tan
T Waldmann
S Kadereit
M Leist
Cell Death & Differentiation, 2011, 18 : 383 - 395
[23] Developmental neurotoxicity testing with human embryonic stem cell-derived in vitro systems: the novel FP7 ESNATS tests are available
Bolt, H. M.
ARCHIVES OF TOXICOLOGY, 2013, 87 (01) : 5 - 6
[24] Developmental neurotoxicity testing with human embryonic stem cell-derived in vitro systems: the novel FP7 ESNATS tests are available
H. M. Bolt
Archives of Toxicology, 2013, 87 : 5 - 6
[25] A Novel Design for Decision Rules Based on Statistical Testing Strategies of Binary Endpoints in a Definitive Go/No-Go Single-Treatment Clinical Study
Ming Zhou
Larry Z. Shen
Therapeutic Innovation & Regulatory Science, 2014, 48 : 327 - 335
[26] A Novel Design for Decision Rules Based on Statistical Testing Strategies of Binary Endpoints in a Definitive Go/No-Go Single-Treatment Clinical Study
Zhou, Ming
Shen, Larry Z.
THERAPEUTIC INNOVATION & REGULATORY SCIENCE, 2014, 48 (03) : 327 - 335

← 1 2 3 →