Biodistribution and antitumor activity induced by carboxymethylcellulose conjugates

被引：14

作者：

Uglea, CV

Pârv, A

Corjan, M

Dumitriu, AD

Ottenbrite, RM

机构：

[1] Univ Med & Pharm, Dept Biomed Engn, Iasi 700115, Romania

[2] Univ Al I Cuza, Dept Biol, Iasi, Romania

[3] Virginia Commonwealth Univ, Richmond, VA USA

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 2005年 / 20卷 / 06期

关键词：

carboxymethylcellulose conjugates; bioactive polymers; antitumor activity; tumor accumulation; prolonged serum half-life; drug permeability and retention;

D O I：

10.1177/0883911505059251

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New polymers with antitumor activity were synthesized by conjugating ethyl p-aminobenzoate (benzocaine) and N-hydroxy-2,3-dihydroxybenzamide (Didox) onto carboxymethylcellulose (CMC) and oxidized CMC. The biological tests (in vitro and in vivo) for these CMC derivatives exhibited prolonged half-life in serum, accumulation in the solid tumors, and inhibition of the tumor growth. The latter effect was attributed to the permeability and retention (EPR) effect.

引用

页码：571 / 583

页数：13

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