Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro

被引：49
|
作者：
Lin, WeiWei [2 ]
Chen, Xue [2 ]
Wang, XiaoDong [2 ]
Liu, Jie [2 ]
Gu, XiaoSong [1 ,2 ]
机构：
[1] Nantong Univ, Key Lab Neuroregenerat, Nantong 226001, Peoples R China
[2] Nantong Univ, Jiangsu Prov Key Lab Neuroregenerat, Nantong, Peoples R China
来源：
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL | 2008年 / 44卷 / 1-2期
关键词：
induction; transdifferentiation; bone marrow stromal cells; Schwann cell;
D O I：
10.1007/s11626-007-9064-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Bone marrow stromal cells (MSCs) have the capability of differentiating into mesenchymal and non-mesenchymal lineages. In this study, MSCs isolated from adult Sprague-Dawley rats were cultured to proliferation, followed by in vitro induction under specific conditions. The results demonstrated that MSCs were transdifferentiated into cells with the Schwann cell (SC) phenotypes according to their morphology and immunoreactivities to SC surface markers including S-100, glial fibrillary acidic protein (GFAP) and low-affinity nerve growth factor receptor (p75). Consequently, rat adult MSCs can be induced in vitro to differentiate into SC-like cells, thus developing an abundant and accessible SC reservoir to meet the requirements of constructing tissue engineered nerve grafts for peripheral nerve repair.
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页码：31 / 40
页数：10
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