Synthesis of carbohydrate-conjugated dT analogues using 'Click chemistry'

被引：12

作者：

Jin, Xuanye

Yang, Ruchun

Jin, Peiyuan

Xiao, Qiang ^{[1
]}

Ju, Yong

机构：

[1] Tsinghua Univ, Minist Educ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

[2] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organic Chem, Nanjing 330013, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2007年 / 19期

关键词：

dT analogues; carbohydrate conjugation; Sonogashira reaction; click chemistry;

D O I：

10.1055/s-2007-983881

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new type furo[2,3-d]pyrimidine nucleoside conjugated with various carbohydrates was synthesized using Sonogashira coupling and 'click chemistry'. In the subsequent deprotection of the 4-toluoyl and acetyl groups with catalytic sodium methoxide in methanol, the furo[2,3-d]pyrimidine rearranged to an opened ketone-type structure. Their structures were confirmed on the basis of spectroscopy.

引用

页码：2967 / 2972

页数：6

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