Synthesis of carbohydrate-conjugated dT analogues using 'Click chemistry'

被引：12
|
作者：
Jin, Xuanye
Yang, Ruchun
Jin, Peiyuan
Xiao, Qiang [1 ]
Ju, Yong
机构：
[1] Tsinghua Univ, Minist Educ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
[2] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organic Chem, Nanjing 330013, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2007年 / 19期
关键词：
dT analogues; carbohydrate conjugation; Sonogashira reaction; click chemistry;
D O I：
10.1055/s-2007-983881
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new type furo[2,3-d]pyrimidine nucleoside conjugated with various carbohydrates was synthesized using Sonogashira coupling and 'click chemistry'. In the subsequent deprotection of the 4-toluoyl and acetyl groups with catalytic sodium methoxide in methanol, the furo[2,3-d]pyrimidine rearranged to an opened ketone-type structure. Their structures were confirmed on the basis of spectroscopy.
引用
收藏
页码：2967 / 2972
页数：6
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