Changes in superoxide dismutase activity in liver and lung of old rats

被引：14
|
作者：
Maria, CS [1 ]
Ayala, A [1 ]
Revilla, E [1 ]
机构：
[1] UNIV SEVILLA, FAC FARM, DEPT BIOQUIM BROMATOL & TOXICOL, E-41012 SEVILLE, SPAIN
来源：
FREE RADICAL RESEARCH | 1996年 / 25卷 / 05期
关键词：
superoxide dismutase; aging; antioxidant defense; oxidative damage;
D O I：
10.3109/10715769609149062
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Superoxide dismutase activity was measured in liver and lung from 3 and 24 month-old rats. Both total SOD and Mn-SOD activity decreased significantly in the liver of old rats. Recent results from our laboratory have indicated that during aging, the activity of Cu/Zn-SOD decreases in rat liver and that there is an accumulation of altered protein. It was also shown that the old Cu/Zn-SOD had one histidine fewer than the young one. In the present study, the immunoprecipitation experiments showed that the amount of immunoprecipitable Mn-SOD from liver of old rats was greater than from young ones, but when amino acid residues were measured in purified young and old Mn-SOD from liver, no change was observed. In lung, no significant age-related differences in total SOD, Cu/Zn-SOD and Mn-SOD activity were found, nor was there accumulation of altered protein during aging.
引用
收藏
页码：401 / 405
页数：5
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