Molecular and cellular mechanisms of lymphangiogenesis

被引：43
|
作者：
Al-Rawi, MAA [1 ]
Mansel, RE [1 ]
Jiang, WG [1 ]
机构：
[1] Univ Wales Coll Med, Dept Surg, Cardiff CF14 4XN, S Glam, Wales
来源：
EJSO | 2005年 / 31卷 / 02期
关键词：
lymphangiogenesis; lymphatic markers; podoplanin; Prox-1; LYVE-1;
D O I：
10.1016/j.ejso.2004.08.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Lymphangiogenesis is the growth and formation of new Lymphatic vessels. It occurs in normally developing tissues and in pathological processes like inflammation, wound healing, lymphoedema and in cancer. New molecular markers that are specific to the lymphatic endothelium include: podoplanin, prox-1 and LYVE-1. The molecular mechanisms of lymphangiogenesis are not clear, but vascular endothelial. growth factors (VEGF-C and VEGF-D) within tumours may simulate endothelial. cells within tumour tissues to grow and generate new lymphatics. We report the current knowledge of molecular and cellular mechanisms of lymphangiogenesis. (C) 2004 Elsevier Ltd. All. rights reserved.
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页码：117 / 121
页数：5
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