Regioselective nucleophilic substitution of halogen derivatives of 1-substituted 4-oxo-1,4-dihydroquinoline-3-carboxylic acids

被引：8

作者：

Hermecz, I ^{[1
]}

Vasvari-Debreczy, L ^{[1
]}

Podanyi, B ^{[1
]}

Kereszturi, G ^{[1
]}

Balogh, M ^{[1
]}

Horvath, A ^{[1
]}

Varkonyi, P ^{[1
]}

机构：

[1] Chinoin Chem & Pharmaceut Works Ltd, H-1325 Budapest, Hungary

来源：

HETEROCYCLES | 1998年 / 48卷 / 06期

关键词：

D O I：

10.3987/COM-98-8143

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rate of the nucleophilic displacement of the fluoro atom of 7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate could be enhanced either by the introduction of further fluoro atom(s) into position(s) 6 and/or 8, or by the formation of a boron chelate (e.g. 3). The regioselectivity of the nucleophilic substitution of the chloro atom in 1-substituted 6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids could also be enhanced by the formation of a boron chelate (e.g. 7).

引用

页码：1111 / 1116

页数：6

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