Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK

被引：57

作者：

Vitalini, Michael W.

de Paula, Renato M.

Goldsmith, Charles S.

Jones, Carol A.

Borkovich, Katherine A.

Bell-Pedersen, Deborah ^{[1
]}

机构：

[1] Texas A&M Univ, Fac Genet, Ctr Biol Clocks Res, College Stn, TX 77843 USA

[2] Texas A&M Univ, TAMU Dept Biol 3258, Program Biol Filamentous Fungi, College Stn, TX 77843 USA

[3] Univ Calif Riverside, Dept Plant Pathol & Microbiol, Riverside, CA 92521 USA

[4] Univ Calif Riverside, Program Biochem & Mol Biol, Riverside, CA 92521 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2007年 / 104卷 / 46期

关键词：

circadian output pathway; circadian rhythm; Neurospora crassa; osmotic stress phosphorelay;

D O I：

10.1073/pnas.0704900104

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate cellular processes. Little is known about the output pathways. In this study, we show that the Neurospora crassa osmosensing MAPK pathway, essential for osmotic stress responses, is a circadian output pathway that regulates daily rhythms in the expression of downstream genes. Rhythmic activation of the highly conserved stress-activated p38-type MAPK [Osmotically Sensitive-2 (OS-2)] by the N. crassa circadian clock allows anticipation and preparation for hyperosmotic stress and desiccation that begin at sunrise. These results suggest a conserved role for MAPK pathways in circadian rhythmicity.

引用

页码：18223 / 18228

页数：6

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