Effect of Methyltriclosan on the Functioning of Isolated Rat Liver Mitochondria and Permeability of Liposomal Membranes

被引：0
|
作者：
Tenkov, K. S. [1 ]
Dubinin, M., V [1 ]
Semenova, A. A. [1 ]
Belosludtsev, K. N. [1 ,2 ,3 ]
机构：
[1] Mari State Univ, Yoshkar Ola 424000, Russia
[2] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Oblast, Russia
[3] Russian Acad Sci, Prokhorov Gen Phys Inst, Moscow 119991, Russia
来源：
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY | 2021年 / 15卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
liver mitochondria; methyltriclosan; triclosan; oxidative phosphorylation; MPT pore; liposomes; TRICLOSAN EXPOSURE; METHYL-TRICLOSAN; MECHANISM; TOXICITY; INHIBITION; THYROXINE;
D O I：
10.1134/S1990747821020082
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Effects of methyltriclosan, a biodegradation product of the antimicrobial agent triclosan, on the functional parameters of rat liver mitochondria were studied. It was found that methyltriclosan inhibits the activity of complexes II and IV of the respiratory chain. This causes a decrease in the rate of oxygen consumption by mitochondria in states 3 and 3U(DNP). Methyltriclosan was shown to increase the rate of hydrogen peroxide production by rat liver mitochondria. In addition, methyltriclosan induces permeabilization of both mitochondrial membranes and the liposome membranes. Methyltriclosan, in contrast to triclosan, has a milder effect on organelles and their membranes. Possible mechanisms of methyltriclosan effects on mitochondria and liposomes are discussed.
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页码：147 / 155
页数：9
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