A protocell with fusion and division

被引:10
|
作者
Xu, Bo-Ying [1 ]
Xu, Jian [1 ]
Yomo, Tetsuya [1 ]
机构
[1] East China Normal Univ, Biomed Synthet Biol Res Ctr, Sch Life Sci, Inst Biol & Informat Sci, Shanghai 200062, Peoples R China
关键词
GIANT UNILAMELLAR VESICLES; MEMBRANE-FUSION; ARTIFICIAL CELL; PHOSPHOLIPID-VESICLES; MORPHOLOGICAL-CHANGES; PROTEIN EXPRESSION; SELF-REPRODUCTION; LIPOSOMES; GROWTH; STEP;
D O I
10.1042/BST20190576
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A protocell is a synthetic form of cellular life that is constructed from phospholipid vesicles and used to understand the emergence of life from a nonliving chemical network. To be considered 'living', a protocell should be capable of self-proliferation, which includes successive growth and division processes. The growth of protocells can be achieved via vesicle fusion approaches. In this review, we provide a brief overview of recent research on the formation of a protocell, fusion and division processes of the protocell, and encapsulation of a defined chemical network such as the genetic material. We also provide some perspectives on the challenges and future developments of synthetic protocell research.
引用
收藏
页码:1909 / 1919
页数:11
相关论文
共 50 条
  • [1] A Hypothesis for Protocell Division on the Early Earth
    Gozen, Irep
    ACS NANO, 2019, 13 (10) : 10869 - 10871
  • [2] Coupled growth and division of model protocell membranes
    Zhu, Ting F.
    Szostak, Jack W.
    Journal of the American Chemical Society, 2009, 131 (15): : 5705 - 5713
  • [3] Coupled Growth and Division of Model Protocell Membranes
    Zhu, Ting F.
    Szostak, Jack W.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (15) : 5705 - 5713
  • [4] Mathematical modeling of a minimal protocell with coordinated growth and division
    Surovtsev, Ivan V.
    Zhang, Zhigang
    Lindahl, Paul A.
    Morgan, Jeffrey J.
    JOURNAL OF THEORETICAL BIOLOGY, 2009, 260 (03) : 422 - 429
  • [5] Autonomous model protocell division driven by molecular replication
    Taylor, J. W.
    Eghtesadi, S. A.
    Points, L. J.
    Liu, T.
    Cronin, L.
    NATURE COMMUNICATIONS, 2017, 8
  • [6] Autonomous model protocell division driven by molecular replication
    J. W. Taylor
    S. A. Eghtesadi
    L. J. Points
    T. Liu
    L. Cronin
    Nature Communications, 8
  • [7] Photochemically driven redox chemistry induces protocell membrane pearling and division
    Zhu, Ting F.
    Adamala, Katarzyna
    Zhang, Na
    Szostak, Jack W.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (25) : 9828 - 9832
  • [8] A Robust Pathway for Protocell Growth and Division Under Plausible Prebiotic Conditions
    Zhu, Ting F.
    Szostak, Jack W.
    ORIGINS OF LIFE AND EVOLUTION OF BIOSPHERES, 2009, 39 (3-4): : 349 - 350
  • [9] DNA Length-dependent Division of a Giant Vesicle-based Model Protocell
    Matsuo, Muneyuki
    Kan, Yumi
    Kurihara, Kensuke
    Jimbo, Takehiro
    Imai, Masayuki
    Toyota, Taro
    Hirata, Yuiko
    Suzuki, Kentaro
    Sugawara, Tadashi
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [10] DNA Length-dependent Division of a Giant Vesicle-based Model Protocell
    Muneyuki Matsuo
    Yumi Kan
    Kensuke Kurihara
    Takehiro Jimbo
    Masayuki Imai
    Taro Toyota
    Yuiko Hirata
    Kentaro Suzuki
    Tadashi Sugawara
    Scientific Reports, 9