Nanocomposites drug delivery systems for the healing of bone fractures

被引:22
|
作者
Chen, Jianxian [1 ]
Ashames, Akram [2 ]
Buabeid, Manal Ali [2 ]
Fahelelbom, Khairi Mustafa [3 ]
Ijaz, Muhammad [4 ]
Murtaza, Ghulam [4 ]
机构
[1] Capital Univ Econ & Business, Sch Econ, Beijing, Peoples R China
[2] Ajman Univ, Coll Pharm & Hlth Sci, Ajman, U Arab Emirates
[3] Al Ain Univ, Coll Pharm, Dept Pharmaceut Sci, Al Ain, U Arab Emirates
[4] COMSATS Univ Islamabad, Dept Pharm, Lahore Campus, Islamabad 54000, Pakistan
关键词
Bisphosphonates; Hydrogels; Nanoparticles; Bone marrow stem cells; Growth factors; Calcium phosphate cement; CALCIUM-PHOSPHATE CEMENT; MORPHOGENETIC PROTEINS; SUSTAINED DELIVERY; OSTEOGENIC DIFFERENTIATION; CLINICAL-APPLICATIONS; LIPID NANOPARTICLES; GRAFT SUBSTITUTES; SMALL MOLECULES; LOCAL-DELIVERY; ASPARTIC-ACID;
D O I
10.1016/j.ijpharm.2020.119477
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The skeletal system is fundamental for the structure and support of the body consisting of bones, cartilage, and connective tissues. Poor fracture healing is a chief clinical problem leading to disability, extended hospital stays and huge financial liability. Even though most fractures are cured using standard clinical methods, about 10% of fractures are delayed or non-union. Despite decades of progress, the bone-targeted delivery system is still restricted due to the distinctive anatomical bone features. Recently, various novel nanocomposite systems have been designed for the cell-specific targeting of bone, enhancing drug solubility, improving drug stability and inhibiting drug degradation so that it can reach its target site without being removed in the systemic circulation. Such targeting systems could consist of biological compounds i.e. bone marrow stem cells (BMSc), growth factors, RNAi, parathyroid hormone or synthetic compounds, i.e. bisphosphonates (BPs) and calcium phosphate cement. Hydrogels and nanoparticles are also being employed for fracture healing. In this review, we discussed the normal mechanism of bone healing and all the possible drug delivery systems being employed for the healing of the bone fracture.
引用
收藏
页数:12
相关论文
共 50 条
  • [31] AMINOPEPTIDASE HISTOCHEMISTRY IN HEALING BONE FRACTURES
    MORI, M
    OHTA, T
    OKADA, Y
    MAKINO, M
    MURAKAMI, M
    ACTA HISTOCHEMICA ET CYTOCHEMICA, 1975, 8 (01) : 8 - 17
  • [32] Bioactive wound powders as wound healing dressings and drug delivery systems
    Emami, Shahram
    Ebrahimi, Mohsen
    POWDER TECHNOLOGY, 2023, 423
  • [33] Applications of drug delivery systems, organic, and inorganic nanomaterials in wound healing
    Lo, Samantha
    Mahmoudi, Ebrahim
    Fauzi, Mh Busra
    DISCOVER NANO, 2023, 18 (01)
  • [34] Alginate-based systems: advancements in drug delivery and wound healing
    Al-Roujayee, Abdulaziz S.
    Hilaj, Erina
    Deepak, A.
    Jyothi, S. Renuka
    Hamid, Junainah Abd
    Ariffin, I. A.
    Saraswat, Vivek
    Garg, Avni
    INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2024,
  • [35] Advanced drug delivery systems containing herbal components for wound healing
    Gorain, Bapi
    Pandey, Manisha
    Leng, Ng Hui
    Yan, Cho Wei
    Nie, Kuek Wee
    Kaur, Simran Jeet
    Marshall, Vincent
    Sisinthy, Sreenivas Patro
    Panneerselvam, Jithendra
    Molugulu, Nagashekhara
    Kesharwani, Prashant
    Choudhury, Hira
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 617
  • [36] Drug delivery systems for wound healing treatment of upper airway injury
    Cruz, Denzel Ryan D.
    Zheng, Avery
    Debele, Tilahun
    Larson, Peter
    Dion, Gregory R.
    Park, Yoonjee C.
    EXPERT OPINION ON DRUG DELIVERY, 2024, 21 (04) : 573 - 591
  • [37] Polysaccharide Based Hydrogels in Drug Delivery Systems, Wound Healing, and Agriculture
    Edwin Madivoli
    Chemistry Africa, 2023, 6 : 2281 - 2295
  • [38] Advanced Drug Delivery Systems for Topical Insulin in Diabetic Wound Healing
    Barkhordari, Sheida
    Shahi, Farangis
    Khonakdar, Hossein Ali
    CHEMISTRYSELECT, 2024, 9 (44):
  • [39] Polysaccharide Based Hydrogels in Drug Delivery Systems, Wound Healing, and Agriculture
    Madivoli, Edwin
    CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY, 2023, 6 (05): : 2281 - 2295
  • [40] In vitro skin model for the evaluation of burn healing drug delivery systems
    Barbalho, Geisa N.
    Matos, Breno N.
    Espirito Santo, Maria Eduarda L.
    Silva, Vinicius R. C.
    Chaves, Sacha B.
    Gelfuso, Guilherme M.
    Cunha-Filho, Marcilio
    Gratieri, Tais
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 62