Outcomes Associated with Respiratory Failure for Patients with Cardiogenic Shock and Acute Myocardial Infarction: A Substudy of the CULPRIT-SHOCK Trial

被引:17
|
作者
Gimenez, Maria Rubini [1 ,2 ,3 ]
Miller, P. Elliott [4 ,5 ]
Alviar, Carlos L. [6 ]
van Diepen, Sean [7 ,8 ]
Granger, Christopher B. [9 ]
Montalescot, Gilles [10 ]
Windecker, Stephan [11 ]
Maier, Lars [12 ]
Serpytis, Pranas [13 ,14 ]
Serpytis, Rokas [13 ,14 ]
Oldroyd, Keith G. [15 ]
Noc, Marko [16 ]
Fuernau, Georg [17 ]
Huber, Kurt [18 ,19 ]
Sandri, Marcus [1 ,2 ]
de Waha-Thiele, Suzanne [17 ]
Schneider, Steffen [20 ]
Ouarrak, Taoufik [20 ]
Zeymer, Uwe [21 ,22 ]
Desch, Steffen [1 ,2 ]
Thiele, Holger [1 ,2 ]
机构
[1] Univ Leipzig, Heart Ctr Leipzig, Dept Internal Med Cardiol, D-04289 Leipzig, Germany
[2] Leipzig Heart Inst, D-04289 Leipzig, Germany
[3] Univ Hosp Basel, CRIB, CH-4031 Basel, Switzerland
[4] Yale Univ, Sch Med, Div Cardiovasc Med, 333 Cedar St, New Haven, CT 06520 USA
[5] Yale Natl Clinician Scholars Program, New Haven, CT 06510 USA
[6] NYU, Sch Med, Leon H Charney Div Cardiol, New York, NY 10016 USA
[7] Univ Alberta, Dept Crit Care Med, Edmonton, AB, Canada
[8] Univ Alberta, Dept Med, Div Cardiol, Edmonton, AB, Canada
[9] Duke Clin Res Inst, Cardiol Dept, Durham, NC 27701 USA
[10] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, ACTION Study Grp,Dept Cardiol,Inst Cardiol, F-75013 Paris, France
[11] Univ Bern, Bern Univ Hosp, Inselspital, Dept Cardiol, CH-3010 Bern, Switzerland
[12] Univ Hosp Regensburg, Dept Cardiol, D-93077 Regensburg, Germany
[13] Vilnius Univ, Fac Med, LT-08410 Vilnius, Lithuania
[14] Vilnius Univ Hosp, Santaros Klinikos, LT-08410 Vilnius, Lithuania
[15] Golden Jubilee Natl Hosp, Dept Cardiol, Glasgow G81 4DY, Lanark, Scotland
[16] Univ Med Ctr Ljubljana, Cardiol Dept, Ljubljana 1000, Slovenia
[17] Univ Heart Ctr Luebeck, Cardiol Dept, D-23538 Lubeck, Germany
[18] Wilhelminenhospital, Dept Internal Med Cardiol & Intens Care Med 3, A-2301 Vienna, Austria
[19] Sigmund Freud Univ, Med Sch, A-2301 Vienna, Austria
[20] Inst Herzinfarktforsch, Stat Dept, D-67063 Ludwigshafen, Germany
[21] Hosp City Ludwigshafen, Med Clin B, D-67063 Ludwigshafen, Germany
[22] Inst Herzinfarktforsch, D-67063 Ludwigshafen, Germany
关键词
cardiogenic shock; respiratory failure; mechanical ventilation; non-invasive ventilation; POSITIVE-PRESSURE VENTILATION; MECHANICAL VENTILATION; REVASCULARIZATION; SUPPORT; PEEP;
D O I
10.3390/jcm9030860
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Little is known about clinical outcomes of patients with acute myocardial infraction (AMI) complicated by cardiogenic shock (CS) requiring mechanical ventilation (MV). The aim of this study was to identify the characteristics, risk factors, and outcomes associated with the provision of MV in this specific high-risk population. Methods: Patients with CS complicating AMI and multivessel coronary artery disease from the CULPRIT-SHOCK trial were included. We explored 30 days of clinical outcomes in patients not requiring MV, those with MV on admission, and those in whom MV was initiated within the first day after admission. Results: Among 683 randomized patients included in the analysis, 17.4% received no MV, 59.7% were ventilated at admission and 22.8% received MV within or after the first day after admission. Patients requiring MV had a different risk-profile. Factors independently associated with the provision of MV on admission included higher body weight, resuscitation within 24 h before admission, elevated heart rate and evidence of triple vessel disease. Conclusions: Requiring MV in patients with CS complicating AMI is common and independently associated with mortality after adjusting for covariates. Patients with delayed MV initiation appear to be at higher risk of adverse outcomes. Further research is necessary to identify the optimal timing of MV in this high-risk population.
引用
收藏
页数:11
相关论文
共 50 条
  • [21] Investigator versus Core Lab evaluation of coronary blood flow in PCI of patients in cardiogenic shock: a substudy of the CULPRIT-SHOCK trial
    Zeitouni, M.
    Barthelemy, O.
    Rouanet, S.
    Guedeney, P.
    Hauguel-Moreau, M.
    Hage, G.
    Overtchouk, P.
    Brugier, D.
    Vignolles, N.
    Kerneis, M.
    Silvain, J.
    Collet, J. P.
    Vicaut, E.
    Thiele, H.
    Montalescot, G.
    [J]. EUROPEAN HEART JOURNAL, 2019, 40 : 557 - 557
  • [22] ADP-receptor antagonists in patients with acute myocardial infarction complicated by cardiogenic shock: a pooled IABP-SHOCK II and CULPRIT-SHOCK trial sub-analysis
    Kleeberger, J. A.
    Ouarrak, T.
    Freund, A.
    Fuernau, G.
    Geissler, T.
    Huber, K.
    Noc, M.
    Montalescot, G.
    Clemmensen, P.
    Zeymer, U.
    Desch, S.
    Schneider, S.
    Hausleiter, J.
    Thiele, H.
    Orban, M.
    [J]. EUROPEAN HEART JOURNAL, 2021, 42 : 1513 - 1513
  • [23] Culprit lesion location and outcome in patients with cardiogenic shock complicating myocardial infarction: a substudy of the IABP-SHOCK II-trial
    Fuernau, Georg
    Fengler, Karl
    Desch, Steffen
    Eitel, Ingo
    Neumann, Franz-Josef
    Olbrich, Hans-Georg
    de Waha, Antoinette
    de Waha, Suzanne
    Richardt, Gert
    Hennersdorf, Marcus
    Empen, Klaus
    Hambrecht, Rainer
    Jung, Christian
    Boehm, Michael
    Poess, Janine
    Strasser, Ruth H.
    Schneider, Steffen
    Ouarrak, Taoufik
    Schuler, Gerhard
    Werdan, Karl
    Zeymer, Uwe
    Thiele, Holger
    [J]. CLINICAL RESEARCH IN CARDIOLOGY, 2016, 105 (12) : 1030 - 1041
  • [24] Culprit lesion location and outcome in patients with cardiogenic shock complicating myocardial infarction: a substudy of the IABP-SHOCK II-trial
    Georg Fuernau
    Karl Fengler
    Steffen Desch
    Ingo Eitel
    Franz-Josef Neumann
    Hans-Georg Olbrich
    Antoinette de Waha
    Suzanne de Waha
    Gert Richardt
    Marcus Hennersdorf
    Klaus Empen
    Rainer Hambrecht
    Christian Jung
    Michael Böhm
    Janine Pöss
    Ruth H. Strasser
    Steffen Schneider
    Taoufik Ouarrak
    Gerhard Schuler
    Karl Werdan
    Uwe Zeymer
    Holger Thiele
    [J]. Clinical Research in Cardiology, 2016, 105 : 1030 - 1041
  • [25] Culprit lesion location and outcome in patients with cardiogenic shock complicating myocardial infarction: A substudy of the IABP-SHOCK II-Trial
    Fuernau, G.
    Fengler, K.
    Desch, S.
    Eitel, I.
    de Waha, S.
    Boehm, M.
    Poess, J.
    Schneider, S.
    Schuler, G.
    Werdan, K.
    Zeymer, U.
    Thiele, H.
    [J]. WIENER KLINISCHE WOCHENSCHRIFT, 2016, 128 : S271 - S272
  • [26] Prognostic impact of SYNTAX Score in patients with myocardial infarction with multivessel coronary artery disease and cardiogenic shock: insight from the CULPRIT-SHOCK Trial
    Guedeney, P.
    Barthelemy, O.
    Zeitouni, M.
    Hauguel-Moreau, M.
    Hage, G.
    Overtchouk, P.
    Rouanet, S.
    Vicaut, E.
    De Waha-Thiele, S.
    Zeymer, U.
    Sandri, M.
    Akin, I.
    Desch, S.
    Thiele, H.
    Montalescot, G.
    [J]. EUROPEAN HEART JOURNAL, 2019, 40 : 642 - 642
  • [27] Multivessel versus culprit lesion only percutaneous revascularization plus potential staged revascularization in patients with acute myocardial infarction complicated by cardiogenic shock: Design and rationale of CULPRIT-SHOCK trial
    Thiele, Holger
    Desch, Steffen
    Piek, Jan J.
    Stepinska, Janina
    Oldroyd, Keith
    Serpytis, Pranas
    Montalescot, Gilles
    Noc, Marko
    Huber, Kurt
    Fuernau, Georg
    de Waha, Suzanne
    Meyer-Saraei, Roza
    Schneider, Steffen
    Windecker, Stephan
    Savonitto, Stefano
    Briggs, Andrew
    Torremante, Patrizia
    Vrints, Christiaan
    Schuler, Gerhard
    Ceglarek, Uta
    Thiery, Joachim
    Zeymer, Uwe
    [J]. AMERICAN HEART JOURNAL, 2016, 172 : 160 - 169
  • [28] Culprit Lesion Location and Outcome in Patients with Cardiogenic Shock Complicating Myocardial Infarction: A Substudy of the IABP-SHOCK II-Trial
    Fuernau, Georg
    Fengler, Karl
    Desch, Steffen
    Eitel, Ingo
    Neumann, Franz-Josef
    de Waha, Antoinette
    de Waha, Suzanne
    Richardt, Gert
    Empen, Klaus
    Hambrecht, Rainer
    Jung, Christian
    Boehm, Michael
    Poess, Janine
    Schuler, Gerhard
    Werdan, Karl
    Zeymer, Uwe
    Thiele, Holger
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 66 (15) : B89 - B90
  • [29] Prognostic implications of microcirculatory perfusion versus macrocirculatory perfusion in cardiogenic shock: a CULPRIT-SHOCK substudy
    Wijntjens, Gilbert W. M.
    Fengler, Karl
    Fuernau, Georg
    Jung, Christian
    den Uil, Corstiaan
    Akin, Sakir
    van de Hoef, Tim P.
    Serpytis, Rokas
    Diletti, Roberto
    Henriques, Jose P. S.
    Serpytis, Pranas
    Thiele, Holger
    Piek, Jan J.
    [J]. EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, 2020, 9 (02) : 108 - 119
  • [30] Lesion Location and Outcome in Patients With Multi-Vessel Disease and Acute Myocardial Infarction-Related Cardiogenic Shock, a Sub-Analysis of the Culprit-Shock Trial
    Hauguel-Moreau, Marie
    Barthelemy, Olivier
    Zeitouni, Michel
    Guedeney, Paul
    Rouanet, Stephanie
    Hage, Georges
    Overtchouk, Pavel
    Bertin, Benjamin
    Brugier, Delphine
    Vignolles, Nicolas
    Kerneis, Mathieu
    Silvain, Johanne
    Collet, Jean-Philippe
    Vicaut, Eric
    Farhan, Serdar
    Zeymer, Uwe
    Thiele, Holger
    Montalescot, Gilles
    [J]. CIRCULATION, 2019, 140