Central administration of urocortin inhibits vasopressin release in conscious rats

被引：21
|
作者：
Kakiya, S
Yokoi, H
Arima, H
Iwasaki, Y
Oki, Y
Oiso, Y
机构：
[1] Nagoya Univ, Sch Med, Dept Internal Med 1, Showa Ku, Nagoya, Aichi 466, Japan
[2] Hamamatsu Univ Sch Med, Dept Med, Div 2, Hamamatsu, Shizuoka 43131, Japan
来源：
NEUROSCIENCE LETTERS | 1998年 / 248卷 / 02期
关键词：
urocortin; arginine vasopressin; intracerebroventricular injection; osmoregulation;
D O I：
10.1016/S0304-3940(98)00357-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Urocortin (UCN) is a new mammalian member of the corticotropin releasing factor (CRF) family and supposed to be an endogenous ligand for type 2 CRF receptors. Previous studies have revealed that UCN mRNA exists in the supraoptic nucleus (SON), and that water deprivation increases UCN immunoreactivity in SON. In this study. we examined the effect of centrally-administered UCN on arginine vasopressin (AVP) release in conscious rats. Intracerebroventricular (i.c.v.) injection of UCN (5.0 mu g/rat) significantly attenuated AVP release induced by hyperosmolality at 30 min after the injection. In contrast, CRF (5.0 mu g/rat) injected i.c.v. had no significant effect on AVP release. These results suggest that central UCN play an inhibitory role in osmoregulation of AVP release. (C) 1998 Elsevier Science Ireland Ltd. Ail rights reserved.
引用
收藏
页码：144 / 146
页数：3
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