Probing the Antitumor Mechanism of Solanum nigrum L. Aqueous Extract against Human Breast Cancer MCF7 Cells

被引：21
|
作者：
Ling, Binbing [1 ]
Xiao, Shujun [1 ]
Yang, Jinha [1 ]
Wei, Ying [2 ]
Sakharkar, Meena K. [1 ]
Yang, Jian [1 ]
机构：
[1] Univ Saskatchewan, Coll Pharm & Nutr, Drug Discovery & Dev Res Grp, Saskatoon, SK S7N 5E5, Canada
[2] Guizhou Univ Tradit Chinese Med, Coll Pharm, Guiyang 550025, Guizhou, Peoples R China
来源：
BIOENGINEERING-BASEL | 2019年 / 6卷 / 04期
关键词：
Solanum nigrum L; breast cancer; cytotoxicity; cell migration; glycolysis; gene-drug interaction network; gene-disease association network;
D O I：
10.3390/bioengineering6040112
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Solanum nigrum L. is one of the major medicinal plants used to treat cancer. However, the functional mechanism of S. nigrum L. extract is still unknown in spite of numerous studies on its active components. In this study, we probed the potential anticancer mechanism of the aqueous extract of S. nigrum L. (AESN) towards human breast cancer cell line MCF7. At a concentration of 10 g/L, AESN caused 43% cytotoxicity, inhibited the migration, and suppressed the activities of hexokinase and pyruvate kinase by about 30% and 40%, respectively, towards the MCF7 cells. RT2-PCR analysis of a panel of 89 caner-related genes identified 13 upregulated and eight downregulated genes (>2-folds) in MCF7 cells upon AESN treatment. Gene ontology (GO) and functional disease ontology (FunDO) analyses show that the antitumor function of S. nigrum L. involves multiple genes and these genes are shared across other diseases or disorders.
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页数：14
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