Synthesis and characterization of 3-[(2-{(2-(hydrazinocarbonyl)ethyl]sulfanyl}phenyl)amino]propanehydrazide derivatives

被引:0
|
作者
Rutkauskas, Kestutis [1 ]
Tumosiene, Ingrida [1 ]
Mikulskiene, Gema [2 ]
Kantminiene, Kristina [3 ]
Beresnevicius, Zigmuntas J. [1 ]
机构
[1] Kaunas Univ Technol, Dept Organ Chem, LT-50254 Kaunas, Lithuania
[2] Vilnius Univ, Inst Biochem, LT-08662 Vilnius, Lithuania
[3] Kaunas Univ Technol, Dept Gen Chem, LT-50254 Kaunas, Lithuania
来源
CHEMIJA | 2011年 / 22卷 / 04期
关键词
hydrazide; hydrazone; pyrrole; pyrazole; NMR; NMR CHEMICAL-SHIFTS; ANTIMICROBIAL ACTIVITIES; ROTATIONAL BARRIERS; C-13; HYDRAZONE; PYRAZOLES; PROTONATION; IR;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A series of 3-[(2-{(2-(hydrazinecarbonyl)ethyl]sulfanyl}pheny)amino]propanehydrazide derivatives containing identically ortho-NH/S-substituted benzene moiety were synthesized. The structure of the obtained compounds was proved by combining elemental analysis, mass spectrometry, and H-1 C-13 NMR spectroscopy. The H-1/C-13 2D (HETCOR), H-1/H-1 2D (COSY), DEPT (C-13), NOE (H-1) NMR methods and molecular modeling (MM2) were used for structure elucidation in more complicated cases. Supplementary sets of resonances, observed in the H-1 and C-13 NMR spectra of the majority of synthesized compounds, are explained in terms of peculiar structural features.
引用
收藏
页码:238 / 247
页数:10
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