The efferent medial olivocochlear-hair cell synapse

被引：58

作者：

Belen Elgoyhen, Ana ^{[1
,2
]}

Katz, Eleonora ^{[1
,3
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Inst Invest Ingn Genet & Biol Mol, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Med, Tercera Catedra Farmacol, RA-1428 Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol Biol Mol & Celular, RA-1428 Buenos Aires, DF, Argentina

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 2012年 / 106卷 / 1-2期

关键词：

Hair cells; Nicotinic receptors; alpha 9 and alpha 10 Nicotinic receptors; Synaptic plasticity; Prestin; Cochlea; SK channels; NICOTINIC ACETYLCHOLINE-RECEPTOR; CA2+-ACTIVATED K+ CHANNELS; GENE-RELATED PEPTIDE; CHOLINERGIC-RECEPTOR; SMALL-CONDUCTANCE; ACH RECEPTOR; TRANSMITTER RELEASE; SK2; CHANNELS; PHARMACOLOGICAL CHARACTERIZATION; DEVELOPMENTAL REGULATION;

D O I：

10.1016/j.jphysparis.2011.06.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of alpha 9 and alpha 10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：47 / 56

页数：10

共 50 条

[41] Influence of contralateral noise on distortion product latency in humans: Is the medial olivocochlear efferent system involved?
Giraud, AL
Wable, J
Chays, A
Collet, L
CheryCroze, S
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1997, 102 (04): : 2219 - 2227
[42] Electrically Evoked Medial Olivocochlear Efferent Effects on Stimulus Frequency Otoacoustic Emissions in Guinea Pigs
Berezina-Greene, Maria A.
Guinan, John J., Jr.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 2017, 18 (01): : 153 - 163
[43] Single-unit labeling of medial olivocochlear neurons: the cochlear frequency map for efferent axons
Brown, M. Christian
JOURNAL OF NEUROPHYSIOLOGY, 2014, 111 (11) : 2177 - 2186
[44] Responses of medial olivocochlear neuronsSpecifying the central pathways of the medial olivocochlear reflex
M. C. Brown
R. K. de Venecia
J. J. Guinan
Experimental Brain Research, 2003, 153 : 491 - 498
[45] Electrically Evoked Medial Olivocochlear Efferent Effects on Stimulus Frequency Otoacoustic Emissions in Guinea Pigs
Maria A. Berezina-Greene
John J. Guinan
Journal of the Association for Research in Otolaryngology, 2017, 18 : 153 - 163
[46] Repeatability of Click-Evoked Otoacoustic Emission-Based Medial Olivocochlear Efferent Assay
Mishra, Srikanta K.
Lutman, Mark E.
EAR AND HEARING, 2013, 34 (06): : 789 - 798
[47] Frequency tuning of medial-olivocochlear-efferent acoustic reflexes in humans as functions of probe frequency
Lilaonitkul, Watjana
Guinan, John J., Jr.
JOURNAL OF NEUROPHYSIOLOGY, 2012, 107 (06) : 1598 - 1611
[48] Evaluation of medial olivocochlear efferent system and hearing loss in patients with primary Sjogren's syndrome
Gunduz, Bulent
Yildirim, Nuriye
Guven, Serdar Can
Orhan, Emre
Karamert, Recep
Gunendi, Zafer
TURKISH JOURNAL OF MEDICAL SCIENCES, 2019, 49 (06) : 1647 - 1654
[49] Transmission at the hair cell synapse
Trussell, LO
NATURE NEUROSCIENCE, 2002, 5 (02) : 85 - 86
[50] Transmission at the hair cell synapse
Laurence O. Trussell
Nature Neuroscience, 2002, 5 : 85 - 86

← 1 2 3 4 5 →