SYNTHESIS AND ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW PYRIMIDIN-2(5H)-ONE/THIONE AND 4H-CHROMEN-4-ONE DERIVATIVES

被引：3
|
作者：
Bansode, T. N. [1 ]
Ansari, R. M. [1 ]
Gawale, Y. K. [1 ]
机构：
[1] BNN Coll, Dept Chem, Bhiwani 421305, Thane MS, India
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 45卷 / 06期
关键词：
Chromones; pyrimidinone/thiones; synthesis; antimicrobial properties; ANTIMICROBIAL ACTIVITY; AGENTS; FLAVONOIDS; CHALCONES;
D O I：
10.1007/s11094-011-0635-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new synthesis of 2-substituted-4H-chromen-4-ones (IVa-c) and 4-(2-hydroxyphenyl)-6-substituted pyrimidin- 2(5H)-one/thiones (Va - Vc)/(VIa - VIc) derivatives is reported. First, benzoyloxy esters are converted into their 1,3-diones (IIIa - IIIc) by using dry KOH in pyridine via the Baker - Venkataraman transformation reaction. Then, 1,3-diones thus obtained are cyclised into 2-substituted-4H-chromen-4-ones (IVa - IVc) and 4-(2-hydroxyphenyl)-6-substituted pyrimidin-2(5H)-one/thiones (Va - Vc)/(VIa - VIc) by refluxing in acetic acid and urea/thiourea in ethanol, respectively. The newly synthesized compounds were characterized by IR, H-1 NMR, and mass spectroscopy and elemental analysis and tested for their antibacterial and antifungal activity.
引用
收藏
页码：366 / 368
页数：3
相关论文
共 50 条
  • [41] Synthesis and antimicrobial activity of 5-(2-aminothiazol-4-yl)-3, 4-dihydro-4-phenyl pyrimidin-2(1H)-one
    Lanjewar, Kushal R.
    Rahatgaonkar, Anjali M.
    Chorghade, Mukund S.
    Saraf, Binda D.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (12): : 1732 - 1737
  • [42] In vitro evaluation of the antibacterial and antifungal activity of some new pyrazolyl-quinazolin-4(3H)-one derivatives
    Patel, Navin B.
    Patel, Jaymin C.
    Barat, Gaman G.
    MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (02) : 229 - 238
  • [43] In vitro evaluation of the antibacterial and antifungal activity of some new pyrazolyl-quinazolin-4(3H)-one derivatives
    Navin B. Patel
    Jaymin C. Patel
    Gaman G. Barat
    Medicinal Chemistry Research, 2012, 21 : 229 - 238
  • [44] SYNTHESIS, ANTIOXIDANT AND DFT STUDY OF SOME 4-METHYL-2H-CHROMEN-2-ONE DERIVATIVES
    Bouasla, Souad
    Sobhi, Chafia
    Allal, Hamza
    Mecibah, Wahiba
    Cherifif, Mouna
    Bougdahc, Issam
    REVUE ROUMAINE DE CHIMIE, 2021, 66 (07) : 653 - 660
  • [45] Synthesis and antifungal activities of novel 5-amino-6-arylamino1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives
    Wang, Hong-Qing
    Zhou, Wei-Pimg
    Wang, Yu-Yuan
    Lin, Can-Rong
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2008, 56 (16) : 7321 - 7325
  • [46] Synthesis of some novel pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives as potential antimicrobial agent
    Sureja, Dipen K.
    Dholakia, Sandip P.
    Vadalia, Kantilal R.
    JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2016, 8 (04): : 321 - 326
  • [47] Synthesis and Antiviral Activity of 2-aryl-4H-chromen-4-one Derivatives Against Chikungunya Virus
    Badavath, Vishnu N.
    Jadav, Surender S.
    Pastorino, Boris
    de Lamballerie, Xavier
    Sinha, Barij N.
    Jayaprakash, Venkatesan
    LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 13 (10) : 1019 - 1024
  • [48] One-pot synthesis of new functionalized 4H-chromen-4-ylidene derivatives
    Saeni, Vosough
    Bayat, Mohammad
    Hosseini, Fahimeh Sadat
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2021, 58 (10) : 1962 - 1970
  • [49] Synthesis of New Furan-2(5H)-one Derivatives Containing a 4-Oxothiazolidine Ring
    Karapetyan, L. V.
    Tokmajyan, G. G.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 60 (04) : 650 - 654
  • [50] Synthesis, characterization and antinociceptive activities of Novel 2-(2,4-dichlorophenyl)-4H-chromen-4-one
    Shoaib, Mohammad
    Shah, Syed Wadood Ali
    Shah, Shafiullah
    Khan, Nawaz
    Ahmed, Muhammad Naeem
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 30 (06) : 2085 - 2089
12345