Sero-Surveillance to Monitor the Trend of SARS-CoV-2 Infection Transmission in India: Study Protocol for a Multi Site, Community Based Longitudinal Cohort Study

被引:1
|
作者
Nair, Divya [1 ]
Raju, Reshma [2 ]
Roy, Sudipto [3 ]
Dandge, Shailendra [4 ]
Purushothaman, Girish Kumar Chethrapilly [5 ]
Jayaraman, Yuvaraj [5 ]
Kangusamy, Boopathi [5 ]
Shrivastava, Rahul [6 ]
Arora, Narendra Kumar [1 ]
Rose, Winsley [2 ]
Juvekar, Sanjay [7 ]
Jammy, Guru Rajesh [4 ]
Singh, Kavita [6 ]
Mehendale, Sanjay [8 ]
Rajkumar, Prabu [5 ]
Malik, Shikha Taneja [6 ]
机构
[1] Int Clin Epidemiol Network INCLEN Trust Int, Dept Res, New Delhi, India
[2] Christian Med Coll & Hosp, Dept Pediat, Vellore, India
[3] Indian Council Med Res, Div Epidemiol & Communicable Dis, New Delhi, India
[4] Soc Hlth Allied Res & Educ India, Hyderabad, India
[5] Natl Inst Epidemiol, Indian Council Med Res ICMR, Chennai, India
[6] Biotechnol Ind Res Assistance Council, New Delhi, India
[7] King Edward Mem KEM Hosp Res Ctr, Vadu Rural Hlth Program, Pune, India
[8] Parmanand Deepchand PD Hinduja Hosp, Med Res Ctr, Mumbai, India
关键词
SARS-CoV-2; sero-surveillance; epidemiological studies; cohort; COVID-19; acute febrile illness surveillance;
D O I
10.3389/fpubh.2022.810353
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Introduction: Large-scale sero-prevalence studies with representation from all age groups are required to estimate the true burden of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the community. Serial serological surveys in fixed cohorts enable study of dynamics of viral transmission and correlates of immune response over time in the context of gradual introduction of COVID-19 vaccines and repeated upsurge of cases during the pandemic. Methods: This longitudinal study will involve follow-up of a cohort of 25,000 individuals (5,000 per site) aged 2 years and above recruited from five existing demographic surveillance sites in India. The cohort will be tested for the presence of IgG antibodies against S1/S2 spike protein subunits of SARS-CoV-2 in four rounds; once at baseline and subsequently, at intervals of 4 months for a year between January 2021 and January 2022. Neutralization assays will be carried out in a subset of seropositive samples in each round to quantify the antibody response and to estimate the durability of antibody response. Serial serological surveys will be complemented by fortnightly phone based syndromic surveillance to assess the burden of symptomatic acute febrile illness/ influenza like illness in the same cohort. A bio-repository will also be established to store the serum samples collected in all rounds of serological surveys. Discussion: The population based sero-epidemiological studies will help to determine the burden of COVID-19 at the community level in urban and rural Indian populations and guide in monitoring the trends in the transmission of SARS-CoV-2 infection. Risk factors for infection will be identified to inform future control strategies. The serial serological surveys in the same set of participants will help determine the viral transmission dynamics and durability of neutralizing immune response in participants with or without symptomatic COVID infection.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Infection and reinfection with SARS-CoV-2 in cancer patients: A cohort study
    Nitipir, Cornelia
    Parosanu, Andreea Ioana
    Olaru, Mihaela
    Popa, Ana Maria
    Pirlog, Cristina
    Iaciu, Cristian
    Vrabie, Radu
    Stanciu, Miruna Ioana
    Oprescu-Macovei, Anca
    Bumbacea, Dragos
    Negrei, Carolina
    Orlov-Slavu, Cristina
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2022, 23 (06)
  • [22] University population-based prospective cohort study of SARS-CoV-2 infection and immunity (SARSSURV-ULiege): a study protocol
    Donneau, Anne-Francoise
    Guillaume, Michele
    Bours, Vincent
    Dandoy, Margaux
    Darcis, Gilles
    Desmecht, Daniel
    Diep, Anh Nguyet
    Fievez, Laurence
    Garigliany, Mutien-Marie
    Gillain, Nicolas
    Husson, Eddy
    Michel, Fabienne
    Moutschen, Michel
    Paridans, Marine
    Benoit, Petre
    Sabatel, Catherine
    Saegerman, Claude
    Tytgat, Amandine
    Gillet, Laurent
    Bureau, Fabrice
    BMJ OPEN, 2022, 12 (01):
  • [23] The Impact of SARS-CoV-2 Infection on Sleep, Daytime Sleepiness, and Depression-Longitudinal Cohort Study
    Putenis, Klavs
    Strautmane, Sintija
    Micule, Madara
    Kocane, Evelina
    Karelis, Guntis
    MEDICINA-LITHUANIA, 2024, 60 (08):
  • [24] Longitudinal neutralizing antibody responses after SARS-CoV-2 infection: A convalescent cohort study in Taiwan
    Huang, Yen-Fang
    Hsu, Fang-Chi
    Wu, Jiunn-Jong
    Lin, Yi-Ling
    Liu, Ming-Tsan
    Yang, Chin-Hui
    Kuo, Hsu-Sung
    Chen, Yen-Ju
    Cheng, Chien-Yu
    Lin, His-Hsun
    Liao, Chun-Che
    Chang, Chih-Shin
    Liang, Jian-Jong
    Cheng, Wen-Yueh
    Huang, Jason C.
    Chen, Cheng-Pin
    Cheng, Shu-Hsing
    Lin, Yi-Chun
    Yang, Shung-Haur
    Chou, Yiing-Jenq
    JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2023, 56 (03) : 506 - 515
  • [25] SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study
    Ciccone, Emily J.
    Zivich, Paul N.
    Lodge, Evans K.
    Zhu, Deanna
    Law, Elle
    Miller, Elyse
    Taylor, Jasmine L.
    Chung, Suemin
    Xu, Jason
    Volfovsky, Alexander
    Beatty, Cherese
    Abernathy, Haley
    King, Elise
    Garrett, Haley E.
    Markmann, Alena J.
    Rebuli, Meghan E.
    Sellers, Subhashini
    Weber, David J.
    Reyes, Raquel
    Alavian, Naseem
    Juliano, Jonathan J.
    Boyce, Ross M.
    Aiello, Allison E.
    JMIR RESEARCH PROTOCOLS, 2021, 10 (04):
  • [26] Longitudinal Molecular and Serological Evidence of SARS-CoV-2 Infections and Vaccination Status: Community-Based Surveillance Study (CONTACT)
    Olga Sánchez-Soliño
    Ryan D. Kilpatrick
    Christopher Johnson
    Yixin Fang
    Yizhou Ye
    Negar Niki Alami
    Katarzyna Zarish
    Whitney S. Krueger
    Nancy Dreyer
    Gregory C. Gray
    Infectious Diseases and Therapy, 2024, 13 : 633 - 645
  • [27] Longitudinal Molecular and Serological Evidence of SARS-CoV-2 Infections and Vaccination Status: Community-Based Surveillance Study (CONTACT)
    Sanchez-Solino, Olga
    Kilpatrick, Ryan D.
    Johnson, Christopher
    Fang, Yixin
    Ye, Yizhou
    Alami, Negar Niki
    Zarish, Katarzyna
    Krueger, Whitney S.
    Dreyer, Nancy
    Gray, Gregory C.
    INFECTIOUS DISEASES AND THERAPY, 2024, 13 (04) : 633 - 645
  • [28] Risk of surgical site infection in hand trauma, and the impact of the SARS-CoV-2 pandemic: A cohort study
    Baldwin, Alexander J.
    Jackowski, Anna
    Jamal, Aiman
    Vaz, James
    Rodrigues, Jeremy N.
    Tyler, Michael
    Murray, Alexandra
    Wormald, Justin C. R.
    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 2021, 74 (11): : 3080 - 3086
  • [29] At-home testing to mitigate community transmission of SARS-CoV-2: protocol for a public health intervention with a nested prospective cohort study
    Ciccone, Emily J.
    Conserve, Donaldson F.
    Dave, Gaurav
    Hornik, Christoph P.
    Kuhn, Marlena L.
    Herling, Jessica L.
    Song, Michelle
    Alston, Shani
    Singler, Lindsay
    Schmidt, Michael D.
    Jones, Aaron
    Broderick, Samuel
    Wruck, Lisa M.
    Kibbe, Warren A.
    Aiello, Allison E.
    Woods, Christopher W.
    Richmond, Alan
    Cohen-Wolkowiez, Michael
    Corbie-Smith, Giselle
    BMC PUBLIC HEALTH, 2021, 21 (01)
  • [30] At-home testing to mitigate community transmission of SARS-CoV-2: protocol for a public health intervention with a nested prospective cohort study
    Emily J. Ciccone
    Donaldson F. Conserve
    Gaurav Dave
    Christoph P. Hornik
    Marlena L. Kuhn
    Jessica L. Herling
    Michelle Song
    Shani Alston
    Lindsay Singler
    Michael D. Schmidt
    Aaron Jones
    Samuel Broderick
    Lisa M. Wruck
    Warren A. Kibbe
    Allison E. Aiello
    Christopher W. Woods
    Alan Richmond
    Michael Cohen-Wolkowiez
    Giselle Corbie-Smith
    BMC Public Health, 21