Induction of IFN-g production by IL-12 and IL-18: a link between innate and acquired immune responses

被引：0

作者：

Darwich, L. ^{[1
,2
]}

Jimenez, E. ^{[2
]}

Gomas, G. ^{[2
]}

Pena, R. ^{[2
]}

Blanco, J. ^{[2
]}

Este, J. A. ^{[2
]}

Clotel, B. ^{[2
]}

Ruiz, L. ^{[2
]}

Borras, F. E.

Bolill, M. ^{[2
,3
,4
]}

机构：

[1] Univ Autonoma Barcelona, Barcelona, Spain

[2] Irsicaixa Fdn, Barcelona, Spain

[3] Fundacio Germans Trias & Pujol, Badalona, Spain

[4] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

来源：

2ND EUROPEAN CONGRESS OF IMMUNOLOGY (ECI) | 2009年

关键词：

(IL)-12 PLUS IL-18; INTERFERON-GAMMA; MACROPHAGES;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have described a possible role for IL-12 and IL-18 in the initiation, and resolution of innate immune response to pathogens, as they can induce the aggregation and maturation of monocytes, the induction of inflammatory chemokines (CXCL-8, CCL2, CXCL9, CXCL10). They also induce the production of IFN gamma in the absence of NK or T-cells, suggesting a role for INF gamma in innate immunity.

引用

页码：561 / +

页数：2

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