Oxidative stress in type 1 diabetes

被引：139
|
作者：
Haskins, K
Bradley, B
Powers, K
Fadok, V
Flores, S
Ling, XF
Pugazhenthi, S
Reusch, J
Kench, J
机构：
[1] Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80206 USA
[2] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80206 USA
[3] Natl Jewish Med & Res Ctr, Denver, CO USA
[4] Univ Colorado, Hlth Sci Ctr, Webb Waring Inst Antioxidant Res, Denver, CO 80206 USA
[5] VA Med Ctr, Denver, CO USA
来源：
IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN | 2003年 / 1005卷
关键词：
oxidative stress; SOD mimetic; autoimmune diabetes;
D O I：
10.1196/annals.1288.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We have been investigating the effects of preventing oxidative stress on pathogenesis and complications of type 1 diabetes in the NOD mouse model. Our studies have shown that damage caused by oxidative stress is higher in islets and vascular tissue of NOD mice than in nonautoimmune controls or a diabetes-resistant NOD mouse. In addition, phagocytic function and cytokine production by macrophages are aberrant in the NOD. We have demonstrated that treatment of prediabetic NOD mice for 2 weeks with a metalloporphyrin superoxide dismutase (SOD) mimetic results in marked reduction of oxidative stress in islets and vascular tissue and a reversal of macrophage defects.
引用
收藏
页码：43 / 54
页数：12
相关论文
共 50 条
  • [41] Oxidative stress biology and cell injury during type 1 and type 2 diabetes Mellitus
    Maiese, Kenneth
    Morhan, Simona Daniela
    Chong, Zhao Zhong
    CURRENT NEUROVASCULAR RESEARCH, 2007, 4 (01) : 63 - 71
  • [42] OXIDATIVE STRESS AND PROTEOLYSIS SYSTEM IN TYPE 2 DIABETES
    Dyakov, Denis A.
    Akbasheva, Olga E.
    DIABETES MELLITUS, 2022, 25 (01): : 14 - 20
  • [43] Oxidative Stress and Mitochondrial Dysfunction in Type 2 Diabetes
    Victor, Victor M.
    Rocha, Milagros
    Herance, Raul
    Hernandez-Mijares, Antonio
    CURRENT PHARMACEUTICAL DESIGN, 2011, 17 (36) : 3947 - 3958
  • [44] Oxidative stress in endothelial cells and in diabetes type 2
    Eckers, A.
    Altschmied, J.
    Haendeler, J.
    ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 2012, 45 (02): : 90 - 94
  • [45] Lipids and oxidative stress in type 2 diabetes mellitus
    Zamaklar, M
    Lalic, K
    Rajkovic, N
    Popovic, LJ
    Trifunovic, D
    Potpara, T
    Draskovic, D
    Vasovic, O
    ATHEROSCLEROSIS SUPPLEMENTS, 2005, 6 (01) : 83 - 83
  • [46] Exercise and oxidative stress in type 2 diabetes mellitus
    Poblete-Aro, Carlos
    Russell-Guzman, Javier
    Parra, Pablo
    Soto-Munoz, Marcelo
    Villegas-Gonzalez, Bastian
    Cofre-Bolados, Cristian
    Herrera-Valenzuela, Tomas
    REVISTA MEDICA DE CHILE, 2018, 146 (03) : 362 - 372
  • [47] OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH TYPE 2 DIABETES
    Gawlik, K.
    Pawlica, D.
    Grudzien, U.
    Solnica, B.
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2011, 49 : S379 - S379
  • [48] Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
    Hideaki Kaneto
    Taka-aki Matsuoka
    Yoshihisa Nakatani
    Dan Kawamori
    Takeshi Miyatsuka
    Munehide Matsuhisa
    Yoshimitsu Yamasaki
    Journal of Molecular Medicine, 2005, 83 : 429 - 439
  • [49] Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes
    Kaneto, H
    Matsuoka, T
    Nakatani, Y
    Kawamori, D
    Miyatsuka, T
    Matsuhisa, M
    Yamasaki, Y
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2005, 83 (06): : 429 - 439
  • [50] Oxidative and carbonyl stress in relation to polyneuropathy in subjects with recently diagnosed type 1 and type 2 diabetes
    Ziegler, D.
    Strom, A.
    Kaul, K.
    Rokitta, I.
    Fleming, T. H.
    Puettgen, S.
    Brueggemann, J.
    Ziegler, I.
    Ringel, B.
    Szendroedi, J.
    Nawroth, P. P.
    Roden, M.
    DIABETOLOGIA, 2015, 58 : S108 - S109
12345