K13-Propeller Polymorphisms in Plasmodium falciparum Parasites From Sub-Saharan Africa

被引：186

作者：

Kamau, Edwin ^{[1
]}

Campino, Susana ^{[2
]}

Amenga-Etego, Lucas ^{[4
]}

Drury, Eleanor ^{[2
]}

Ishengoma, Deus ^{[6
]}

Johnson, Kimberly ^{[3
]}

Mumba, Dieudonne ^{[7
]}

Kekre, Mihir ^{[2
]}

Yavo, William ^{[8
]}

Mead, Daniel ^{[2
]}

Bouyou-Akotet, Marielle ^{[9
]}

Apinjoh, Tobias ^{[10
]}

Golassa, Lemu ^{[11
,12
]}

Randrianarivelojosia, Milijaona ^{[13
]}

Andagalu, Ben ^{[1
]}

Maiga-Ascofare, Oumou ^{[14
,16
]}

Amambua-Ngwa, Alfred ^{[15
]}

Tindana, Paulina ^{[4
]}

Ghansah, Anita ^{[5
]}

MacInnis, Bronwyn ^{[2
]}

Kwiatkowski, Dominic ^{[2
,3
]}

Djimde, Abdoulaye A. ^{[2
]}

机构：

[1] KEMRI US Army Med Res Unit Kenya, Kisumu, Kenya

[2] Wellcome Trust Sanger Inst, Hinxton, England

[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX1 2JD, England

[4] Univ Ghana, Navrongo Hlth Res Ctr, Legon, Ghana

[5] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Ghana

[6] Natl Inst Med Res, Tanga, Tanzania

[7] Univ Kinshasa, Fac Med, Ecole Sante Publ, Inst Natl Rech Biomed, Kinshasa, DEM REP CONGO

[8] Natl Inst Publ Hlth, Malaria Res & Control Ctr, Abidjan, Cote Ivoire

[9] Univ Sci Sante, Fac Med, Dept Parasitol & Mycol, Libreville, Gabon

[10] Univ Buea, Buea, Cameroon

[11] Univ Addis Ababa, Aklilu Lemma Inst Pathobiol, Addis Ababa, Ethiopia

[12] Armauer Hansen Res Inst, Addis Ababa, Ethiopia

[13] Inst Pasteur Madagascar, Antananarivo, Madagascar

[14] Univ Sci Tech & Technol Bamako, Fac Pharm, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali

[15] MRC, Gambia Unit, Serekunda, Gambia

[16] Benhard Nocht Inst Trop Med, Hamburg, Germany

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 211卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

K13-propeller; artemisinin resistance; sub-Saharan Africa; ARTEMISININ RESISTANCE; MALARIA; CLEARANCE;

D O I：

10.1093/infdis/jiu608

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

引用

页码：1352 / 1355

页数：4

共 50 条

[41] Tackling protozoan parasites of cattle in sub-Saharan Africa
MacGregor, Paula
Nene, Vishvanath
Nisbet, R. Ellen R.
PLOS PATHOGENS, 2021, 17 (10)
[42] Therapy of falciparum malaria in Sub-Saharan Africa: from molecule to policy
Winstanley, P
Ward, S
Snow, R
Breckenridge, A
CLINICAL MICROBIOLOGY REVIEWS, 2004, 17 (03) : 612 - +
[43] An approach to model the costs and effects of case management of Plasmodium falciparum malaria in sub-Saharan Africa
Tediosi, Fabrizio
Maire, Nicolas
Smith, Thomas
Hutton, Guy
Utzinger, Juerg
Ross, Amanda
Tanner, Marcel
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2006, 75 (02): : 90 - 103
[44] Estimates of the changing age-burden of Plasmodium falciparum malaria disease in sub-Saharan Africa
Griffin, Jamie T.
Ferguson, Neil M.
Ghani, Azra C.
NATURE COMMUNICATIONS, 2014, 5
[45] Neurological sequelae of pediatric Plasmodium falciparum cerebral malaria in sub-Saharan Africa: A brief overview
Leslie, Kelly A. A.
UNIVERSITY OF TORONTO MEDICAL JOURNAL, 2019, 96 (03) : 57 - 61
[46] Estimates of the changing age-burden of Plasmodium falciparum malaria disease in sub-Saharan Africa
Jamie T. Griffin
Neil M. Ferguson
Azra C. Ghani
Nature Communications, 5
[47] Impact of home management of Plasmodium falciparum malaria on childhood malaria control in sub-Saharan Africa
Uneke, C. J.
TROPICAL BIOMEDICINE, 2009, 26 (02) : 182 - 199
[48] Modelling the drivers of the spread of Plasmodium falciparum hrp2 gene deletions in sub-Saharan Africa
Watson, Oliver J.
Slater, Hannah C.
Verity, Robert
Parr, Jonathan B.
Mwandagarlirwa, Melchior K.
Tshefu, Antoinette
Meshnick, Steven R.
Ghani, Azra C.
ELIFE, 2017, 6
[49] REFINED SUB-STRUCTURE OF <it>PLASMODIUM FALCIPARUM</it> POPULATIONS IN SUB-SAHARAN AFRICA AND THE IMPLICATIONS FOR THE EMERGENCE AND SPREAD OF ARTEMISININ RESISTANCE
Kamau, Edwin
Amambua-Ngwa, Alfred
Amenga-Etego, Lucas
Ishengoma, Deus
Andagalu, Ben
Djimde, Abdoulaye
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2018, 99 (04): : 652 - 652
[50] The epidemiology and burden of Plasmodium falciparum-related anemia among pregnant women in sub-Saharan Africa
Guyatt, HL
Snow, RW
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2001, 64 (1-2): : 36 - 44

← 1 2 3 4 5 →