Prognostic Value of Coronary CT Angiography-Derived Fractional Flow Reserve in Non-obstructive Coronary Artery Disease: A Prospective Multicenter Observational Study

被引：4

作者：

Zhou, Fan ^{[1
]}

Chen, Qian ^{[2
]}

Luo, Xiao ^{[3
]}

Cao, Wei ^{[4
]}

Li, Ziwen ^{[5
]}

Zhang, Bo ^{[6
]}

Schoepf, U. Joseph ^{[7
]}

Gill, Callum E. ^{[7
]}

Guo, Lili ^{[8
]}

Gao, Hong ^{[9
]}

Li, Qingyao ^{[10
]}

Shi, Yibing ^{[11
]}

Tang, Tingting ^{[12
]}

Liu, Xiaochen ^{[13
]}

Wu, Honglin ^{[14
]}

Wang, Dongqing ^{[15
]}

Xu, Feng ^{[16
]}

Jin, Dongsheng ^{[17
]}

Huang, Sheng ^{[18
]}

Li, Haige ^{[19
]}

Pan, Changjie ^{[20
]}

Gu, Hongmei ^{[21
]}

Xie, Lixiang ^{[22
]}

Wang, Ximing ^{[23
]}

Ye, Jing ^{[24
]}

Jiang, Jianwei ^{[25
]}

Zhao, Hanqing ^{[26
]}

Fang, Xiangming ^{[27
]}

Xu, Yi ^{[28
]}

Xing, Wei ^{[29
]}

Li, Xiaohu ^{[30
]}

Yin, Xindao ^{[2
]}

Lu, Guang Ming ^{[1
]}

Zhang, Long Jiang ^{[1
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Sch Med, Dept Radiol, Nanjing, Peoples R China

[2] Nanjing Med Univ, Nanjing Hosp 1, Dept Radiol, Nanjing, Peoples R China

[3] Peoples Hosp Maanshan, Dept Radiol, Maanshan, Peoples R China

[4] First Peoples Hosp Xuzhou, Dept Radiol, Xuzhou, Peoples R China

[5] Nanjing Med Univ, Lianyungang Clin Med Coll, Dept Radiol, Lianyungang, Peoples R China

[6] Taizhou Peoples Hosp, Dept Radiol, Taizhou, Peoples R China

[7] Med Univ South Carolina, Dept Radiol & Radiol Sci, Div Cardiovasc Imaging, Charleston, SC USA

[8] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Med Imaging, Huaian, Peoples R China

[9] Qinhuai Med Reg Jinling Hosp, Dept Med Imaging, Nanjing, Peoples R China

[10] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Dept Radiol, Nanjing, Peoples R China

[11] Xuzhou Cent Hosp, Dept Diagnost Radiol, Xuzhou, Peoples R China

[12] Nantong Univ, Yancheng Hosp 1, Dept Diagnost Radiol, Affiliated Hosp, Yancheng, Peoples R China

[13] Haian City Peoples Hosp, Dept Med Imaging, Haian, Peoples R China

[14] Jiangsu Univ, Affiliated Wujin Hosp, Dept Radiol, Changzhou, Peoples R China

[15] Jiangsu Univ, Affiliated Hosp, Dept Med Imaging, Zhenjiang, Peoples R China

[16] Nanjing Med Univ, Affiliated Suqian Peoples Hosp 1, Dept Med Imaging, Suqian, Peoples R China

[17] Jiangsu Prov Official Hosp, Jiangsu Jiankang Vocat Coll, Dept Radiol, Nanjing, Peoples R China

[18] Nantong Univ, Affiliated Hosp 2, Dept Radiol, Nantong, Peoples R China

[19] Nanjing Med Univ, Affiliated Hosp 2, Dept Med Imaging, Nanjing, Peoples R China

[20] Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Dept Radiol, Changzhou, Peoples R China

[21] Nantong Univ, Affiliated Hosp, Med Imaging Ctr, Nantong, Peoples R China

[22] Xuzhou Med Univ, Affiliated Hosp, Dept Radiol, Xuzhou, Peoples R China

[23] Soochow Univ, Affiliated Hosp 1, Dept Radiol, Suzhou, Peoples R China

[24] Subei Peoples Hosp Jiangsu Prov, Radiol Dept, Yangzhou, Peoples R China

[25] Jiangnan Univ, Affiliated Hosp, Dept Med Imaging, Wuxi, Peoples R China

[26] Xuzhou Med Univ, Affiliated Huaihai Hosp, Dept Med Imaging, Xuzhou, Peoples R China

[27] Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Dept Radiol, Wuxi, Peoples R China

[28] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiol, Nanjing, Peoples R China

[29] Soochow Univ, Affiliated Hosp 3, Dept Radiol, Changzhou, Peoples R China

[30] Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 8卷

基金：

中国国家自然科学基金;

关键词：

non-obstructive coronary artery disease; coronary computed tomography angiography; fractional flow reserve; major adverse cardiovascular events; coronary plaque assessment; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; MYOCARDIAL-INFARCTION; DIAGNOSTIC PERFORMANCE; RISK STRATIFICATION; GLOBAL BURDEN; HEART; OUTCOMES; PLAQUE; MORTALITY; ISCHEMIA;

D O I：

10.3389/fcvm.2021.778010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Coronary artery disease (CAD) is a major contributor to morbidity and mortality worldwide. Myocardial ischemia may occur in patients with normal or non-obstructive CAD on invasive coronary angiography (ICA). The comprehensive evaluation of coronary CT angiography (CCTA) integrated with fractional flow reserve derived from CCTA (CT-FFR) to CAD may be essential to improve the outcomes of patients with non-obstructive CAD. China CT-FFR Study-2 (ChiCTR2000031410) is a large-scale prospective, observational study in 29 medical centers in China. The primary purpose is to uncover the relationship between the CCTA findings (including CT-FFR) and the outcome of patients with non-obstructive CAD. At least 10,000 patients with non-obstructive CAD but without previous revascularization will be enrolled. A 5-year follow-up will be performed. The primary endpoint is the occurrence of major adverse cardiovascular events (MACE), including all-cause mortality, non-fatal myocardial infarct, unplanned revascularization, and hospitalization for unstable angina. Clinical characteristics, laboratory and imaging examination results will be collected to analyze their prognostic value.

引用

页数：10

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