Coronary CT Angiography-Derived Fractional Flow Reserve

被引:0
|
作者
Sulaiman N. [1 ]
Soon J. [1 ]
Leipsic J. [1 ]
机构
[1] Division of Cardiology, Department of Medical Imaging, St. Paul’s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, V6S 1Y6, BC
关键词
Coronary artery disease; Coronary CT angiography; Coronary CT angiography-derived fractional flow reserve; Invasive coronary angiography;
D O I
10.1007/s40134-016-0170-z
中图分类号
学科分类号
摘要
Purpose of Review: Coronary CT angiography has been shown to be highly diagnostically accurate as compared with invasive coronary angiography and help clinical decision making that affords improved clinical outcomes. Unfortunately, routine coronary CTA does not allow for the discrimination of the hemodynamic significance of stenosis. Recently, through the integration of computational fluid dynamics, Fractional Flow Reserve CT (FFRct) has been developed which allows for the determination of the hemodynamic significance of specific lesions from a resting coronary CTA without additional imaging, a change in protocol or the administration of adenosine. Recent Findings: FFRct has been validated in three large multicenter trials and has been shown to be the most accurate noninvasive test for lesion-specific ischemia as compared with the invasive gold standard of FFR. Importantly, FFRct has been shown also to be highly clinically useful in both trial and real-world settings affording a reduction in the burden of nonobstructive disease at the time of invasive angiography enabling a significant reduction in cost. Summary: FFRct is a novel technique that for the first time allows for a nonbiased noninvasive three-vessel FFR that compares favorably with the invasive gold standard of lesion-specific ischemia. FFRct is proving helpful not only for the adjudication of lesion-specific ischemia but also to help advance our understanding of mechanisms of risk and myocardial infarction. The clinical role of FFRct is being defined with growing registry and real-world data. © 2016, Springer Science+Business Media New York.
引用
收藏
相关论文
共 50 条
  • [1] Coronary CT Angiography-derived Fractional Flow Reserve
    Tesche, Christian
    De Cecco, Carlo N.
    Albrecht, Moritz H.
    Duguay, Taylor M.
    Bayer, Richard R., II
    Litwin, Sheldon E.
    Steinberg, Daniel H.
    Schoepf, U. Joseph
    [J]. RADIOLOGY, 2017, 285 (01) : 17 - 33
  • [2] Coronary angiography-derived contrast fractional flow reserve
    Gong, Yanjun
    Zheng, Bo
    Yi, Tieci
    Yang, Fan
    Hong, Tao
    Liu, Zhaoping
    Huo, Yunlong
    Li, Jianping
    Huo, Yong
    [J]. CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2022, 99 (03) : 763 - 771
  • [3] CT Angiography-derived Fractional Flow Reserve: The Global Game of Thrones
    Schoepf, U. Joseph
    Gray, Hunter N.
    Tesche, Christian
    [J]. RADIOLOGY-CARDIOTHORACIC IMAGING, 2019, 1 (04):
  • [4] Diagnostic accuracy of coronary computed tomography angiography-derived fractional flow reserve
    Wenbing Jiang
    Yibin Pan
    Yumeng Hu
    Xiaochang Leng
    Jun Jiang
    Li Feng
    Yongqing Xia
    Yong Sun
    Jian’an Wang
    Jianping Xiang
    Changling Li
    [J]. BioMedical Engineering OnLine, 20
  • [5] Sex Differences in Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve
    Fairbairn, Timothy A.
    Dobson, Rebecca
    Hurwitz-Koweek, Lyne
    Matsuo, Hitoshi
    Norgaard, Bjarne L.
    Sand, Niels Peter Ronnow
    Nieman, Koen
    Bax, Jeroen J.
    Pontone, Gianluca
    Raff, Gilbert
    Chinnaiyan, Kavitha M.
    Rabbat, Mark
    Amano, Tetsuya
    Kawasaki, Tomohiro
    Akasaka, Takashi
    Kitabata, Hironori
    Binukrishnan, Sukumaran
    Rogers, Campbell
    Berman, Daniel
    Patel, Manesh R.
    Douglas, Pamela S.
    Leipsic, Jonathon
    [J]. JACC-CARDIOVASCULAR IMAGING, 2020, 13 (12) : 2576 - 2587
  • [6] Diagnostic accuracy of coronary computed tomography angiography-derived fractional flow reserve
    Jiang, Wenbing
    Pan, Yibin
    Hu, Yumeng
    Leng, Xiaochang
    Jiang, Jun
    Li Feng
    Xia, Yongqing
    Sun, Yong
    Wang, Jian'an
    Xiang, Jianping
    Li, Changling
    [J]. BIOMEDICAL ENGINEERING ONLINE, 2021, 20 (01)
  • [7] Accuracy and Reproducibility of Coronary Angiography-Derived Fractional Flow Reserve in the Assessment of Coronary Lesion Severity
    Yang, Guojian
    Li, Le
    Peng, Xi
    Tang, Guodong
    Zheng, Naixin
    Zhao, Ying
    Li, Hui
    Zhang, Huiping
    Sun, Fucheng
    Ai, Hu
    [J]. INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2023, 16 : 3805 - 3814
  • [8] Relationship Between Coronary CT Angiography-Derived Fractional Flow Reserve and Clinical Outcomes in Patients With and Without Diabetes
    Gulsin, Gaurav
    Tzimas, Georgios
    Takagi, Hidenobu
    Eddy, Rachel
    Blanke, Philipp
    Park, Park
    Koweek, Lynne
    Norgaard, Bjarne
    Rabbat, Mark
    Fairbairn, Tmothy
    Chinnaiyan, Kavitha
    Douglas, Pamela
    Huey, Whitney
    Matsuo, Hitoshi
    Sand, Niels Peter Ronnow
    Nieman, Koen
    Bax, Jeroen
    Amano, Tetsuya
    Kawasaki, Tomohiro
    Akasaka, Takashi
    Rogers, Campbell
    Berman, Daniel
    Patel, Manesh
    De Bruyne, Bernard
    Mullen, Sarah
    Leipsic, Jonathon
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2021, 78 (19) : B164 - B164
  • [9] Coronary CT angiography-derived fractional flow reserve in-stable angina: association with recurrent chest pain
    Madsen, Kristian Taekker
    Veien, Karsten Tange
    Larsen, Pia
    Husain, Majed
    Deibjerg, Lone
    Junker, Anders
    Kusk, Martin Weber
    Thomsen, Kristian Korsgaard
    Rohold, Allan
    Jensen, Lisette Okkels
    Sand, Niels Peter Ronnow
    [J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2022, 23 (11) : 1511 - 1519
  • [10] The impact of deep learning reconstruction on image quality and coronary CT angiography-derived fractional flow reserve values
    Cheng Xu
    Min Xu
    Jing Yan
    Yan-Yu Li
    Yan Yi
    Yu-Bo Guo
    Ming Wang
    Yu-Mei Li
    Zheng-Yu Jin
    Yi-Ning Wang
    [J]. European Radiology, 2022, 32 : 7918 - 7926